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Mitochondrial respiratory chain defects and developmental diaphragmatic dysfunction in the neonatal period
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Abstract
Mitochondrial respiratory chain disorders are increasingly recognized as common causes of neurological disease and can present at any time from birth through to later in adult life. Although presentation in the neonatal period is rare and few syndromes are described, an association between mitochondrial dysfunction and diaphragmatic problems presenting in the neonatal period has not previously been reported in the literature. Here we report a case series of three newborns that...
Related newspaper, magazine, and journal articles from HighBeam Research
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A two-dimensional electrophoresis preliminary approach to human hepatocarcinoma differentiation induced by PPAR-agonists
Journal of Cellular and Molecular Medicine
; Abstract Adopting biochemical and proteomic approaches, we investigated the effect of some PPAR-agonists, a new class of differentiating agents, on human hepatocellular carcinoma Hep-G2 cell line. Cancer differentiation was assayed by checking albumin, transferrin and α-fetoprotein synthesis.
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Respiratory-chain enzyme activities in isolated mitochondria of lymphocytes from patients with Parkinson's disease: Preliminary study
Neurology India
; Parkinson's disease (PD) may be one of the most baffling and complex of the neurological disorders. Its cause remains a mystery but research in this area is active, with new and intriguing findings constantly being reported. Research into the etiology of PD has focused mainly on toxins that inhibit
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Spectral Unmixing of Flavin Autofluorescence Components in Cardiac Myocytes
Biophysical Journal
; ABSTRACT We applied linear unmixing approach to reveal individual components of intrinsic flavin fluorescence signal recorded in living cardiac cells by spectrally resolved confocal microscopy. Responses of whole-cell autofluorescence to modulators of cell metabolism and respiration were used as a
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Automated Spectrophotometric Analysis of Mitochondrial Respiratory Chain Complex Enzyme Activities in Cultured Skin Fibroblasts
Clinical Chemistry
; Background: Mitochondrial respiratory chain complex (RCC) disorders may occur as commonly as 1 in 8500 individuals. Because of the great variability of phenotypic presentations, measurement of individual RCC enzyme activities is a crucial diagnostic process. Current assay methods are time-consuming
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Clinical features of mitochondrial disease in a family
Journal of Pediatric Neurology
; Abstract. Mitochondrial disorders, once thought to be relatively rare, are now thought to he the most prevalent metabolic disease. They represent a challenge to clinicians, especially in children, in whom clinical presentation and course show enormous variation. We report a respiratory chain enzyme
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