Antagonism of Chk1 Signaling in the G^sub 2^ DNA Damage Checkpoint by Dominant Alleles of Cdr1 From: Genetics | Date: September 1, 2006| Author: Calonge, Teresa M; O'Connell, Matthew J | Copyright Genetics Society of America Sep 2006. Provided by ProQuest LLC.Copyright information

ABSTRACT

Activation of the Chk1 protein kinase by DNA damage enforces a checkpoint that maintains Cdc2 in its inactive, tyrosine-15 (Y15) phosphorylated state. Chk1 downregulates the Cdc25 phosphatases and concomitantly upregulates the Wee1 kinases that control the phosphorylation of Cdc2. Overproduction of Chk1 causes G^sub 2^ arrest/delay independently of DNA damage and upstream checkpoint genes. We utilized this to screen fission yeast for mutations that alter sensitivity to Chk1 si...

Related newspaper, magazine, and journal articles from HighBeam Research

	Mutator Phenotype of Caenorhabditis elegans DNA Damage Checkpoint Mutants Genetics ; ABSTRACT DNA damage response proteins identify sites of DNA damage and signal to downstream effectors that orchestrate either apoptosis or arrest of the cell cycle and DNA repair. The C. elegans DNA damage response mutants mrt-2, hus-1, and clk-2(mn159) displayed 8- to 15-fold increases in the
	Arabidopsis WEE1 Kinase Controls Cell Cycle Arrest in Response to Activation of the DNA Integrity Checkpoint(W)(OA) Plant Cell ; Upon the incidence of DNA stress, the ataxia telangiectasia-mutated (ATM) and Rad3-related (ATR) signaling kinases activate a transient cell cycle arrest that allows cells to repair DNA before proceeding into mitosis. Although the ATM-ATR pathway is highly conserved over species, the mechanisms by
	Arabidopsis WEE1 Kinase Controls Cell Cycle Arrest in Response to DNA Damage Plant Cell ; ... ATR-and ATM-dependent transcriptional upregulation of WEE1 is an important cell cycle checkpoint mechanism in plants. www.plantcell.org/cgi/doi/10.1105/tpc.107.190111 [Author Affiliation] Nancy A. Eckardt News and Reviews Editor neckardt@aspb.org
	Ccr4-Not Complex mRNA Deadenylase Activity Contributes to DNA Damage Responses in Saccharomyces cerevisiae Genetics ; ABSTRACT DNA damage checkpoints regulate gene expression at the transcriptional and post-transcriptional level. Some components of the yeast Ccr4-Not complex, which regulates transcription as well as transcript turnover, have previously been linked to DNA damage responses, but it is unclear if this
	Contribution of Growth and Cell Cycle Checkpoints to Radiation Survival in Drosophila Genetics ; ABSTRACT Cell cycle checkpoints contribute to survival after exposure to ionizing radiation (IR) by arresting the cell cycle and permitting repair. As such, yeast and mammalian cells lacking checkpoints are more sensitive to killing by IR. We reported previously that Drosophila larvae mutant for

See all results.