The Relative Roles of Three DNA Repair Pathways in Preventing Caenorhabditis elegans Mutation Accumulation

From: Genetics | Date: September 1, 2006| Author: Durbin, Matthew; Feinberg, Seth; Lynch, Michael; Steding, Catherine; Denver, Dee R | Copyright information

ABSTRACT

Mutation is a central biological process whose rates and spectra are influenced by a variety of complex and interacting forces. Although DNA repair pathways are generally known to play key roles in maintaining genetic stability, much remains to be understood about the relative roles of different pathways in preventing the accumulation of mutations and the extent of heterogeneity in pathway-specific repair efficiencies across different genomic regions. In this study we examine ...

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