A Model for the Circadian Rhythm of Cyanobacteria that Maintains Oscillation without Gene Expression From: Biophysical Journal | Date: September 15, 2006| Author: | Copyright Biophysical Society Sep 15, 2006. Provided by ProQuest LLC.Copyright information

ABSTRACT

An intriguing property of the cyanobacterial circadian clock is that endogenous rhythm persists when protein abundances are kept constant either in the presence of translation and transcription inhibitors or in the constant dark condition. Here we propose a regulatory mechanism of KaiC phosphorylation for the generation of circadian oscillations in cyanobacteria. In the model, clock proteins KaiA and KaiB are assumed to have multiple states, regulating the KaiC phosphorylation process. The model can explain 1), the sustained oscillation of gene expression and protein abundance when ...

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Japan Science and Technology Agency, Nagoya University Successfully Reconstruct Biological Clock in Test Tube ; ...a living organism measures time. Detailed research results were published in the April 15 issue of US scientific magazine Science under the title of "Reconstruction of Circadian Oscillation of Cyanobacterial KaiC Phosphorylation in Vitro."

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