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Severe Ataxia, Myelopathy, and Peripheral Neuropathy Due to Acquired Copper Deficiency in a Patient With History of Gastrectomy
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ABSTRACT. Background: In animal studies, copper absorption has been demonstrated to occur in the proximal gut via duodenal enterocytes. Acquired copper deficiency is known as "swayback" in ruminant animals and Menkes' disease in humans. Copper is an essential micronutrient necessary for the hematologic and neurologic systems. Acquired copper deficiency in humans has been described, causing a syndrome similar to the subacute combined degeneration of vitamin B12 deficiency. Methods: This is a s...
Related newspaper, magazine, and journal articles from HighBeam Research
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Copper Deficiency Myelopathy (Human Swayback)
Mayo Clinic Proceedings
; The hematologic manifestations of copper deficiency are well known and include anemia and neutropenia. In the past few years, the neurological manifestations of acquired copper deficiency in humans has been recognized, the most common being a myelopathy presenting with a spastic gait and prominent
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Latent Copper Deficiency in Patients Receiving Low-Copper Enteral Nutrition for a Prolonged Period
JPEN, Journal of Parenteral and Enteral Nutrition
; ABSTRACT. Background: Copper deficiency has been reported in patients supported with long-term enteral nutrition. Occasionally, this leads to anemia and leukopenia. There is no detailed report relating to the onset time of copper deficiency and how the symptoms develop. This report describes the
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"Myelodysplasia," Myeloneuropathy, and Copper Deficiency
Mayo Clinic Proceedings
; We describe a patient with a suspected myelodysplastic syndrome that developed in association with a neurologic disorder resembling subacute combined degeneration but without vitamin B12 deficiency. Ultimately, the hematologic manifestations and the neurologic syndrome were linked to severe copper
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Rapid development of severe copper deficiency in a patient with Crohn's Disease receiving parenteral nutrition
JPEN, Journal of Parenteral and Enteral Nutrition
; ABSTRACT. A 32-year-old man with active Crohn's disease and recurrent small bowel strictures underwent abdominal surgery and was subsequently given total parenteral nutrition (TPN). Severe cholestasis developed and copper was removed from the TPN. Although serum ceruloplasmin levels were within
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Severe Ataxia, Myelopathy, and Peripheral Neuropathy Due to Acquired Copper Deficiency in a Patient With History of Gastrectomy
JPEN, Journal of Parenteral and Enteral Nutrition
; ABSTRACT. Background: In animal studies, copper absorption has been demonstrated to occur in the proximal gut via duodenal enterocytes. Acquired copper deficiency is known as "swayback" in ruminant animals and Menkes' disease in humans. Copper is an essential micronutrient necessary for the
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Pancytopenia after removal of copper from total parenteral nutrition
JPEN, Journal of Parenteral and Enteral Nutrition
; ABSTRACT. Patients who develop cholestatic jaundice during chronic total parenteral nutrition (TPN) can develop significant hematologic complications due to hypocupremia if copper supplementation is withheld. A 36-year-old female with short bowel syndrome developed progressive liver dysfunction 6
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Associations of Dietary and Serum Copper with Inflammation, Oxidative Stress, and Metabolic Variables in Adults1,2
The Journal of Nutrition
; Abstract There are conflicting data on the associations between copper and glycemia, plasma lipids, and atherosclerotic diseases. Copper has both pro-oxidant and antioxidant effects. We performed a cross-sectional analysis to investigate the associations between dietary copper intake and metabolic
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Increased Heme Oxygenase-1 Expression during Copper Deficiency in Rats Results from Increased Mitochondrial Generation of Hydrogen Peroxide1-4
The Journal of Nutrition
; ABSTRACT The activity of hepatic heme oxygenase (HO) in rats is elevated in response to copper deficiency. However, the mechanism responsible for the increase in HO activity is poorly understood. Oxidative stress is a common denominator for many of the signals that induce HO-1, the inducible
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Increased rat brain cytochrome c correlates with degree of perinatal copper deficiency rather than apoptosis1
The Journal of Nutrition
; ABSTRACT Reductions in copper due to dietary restriction or transporter deficiency in brindled mice or humans with Menkes disease lead to reduced cuproenzyme activities, mitochondrial abnormalities, neurodegeneration and early mortality. The mechanisms for observed neuropathology remain unknown.
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Cardiovascular disease from cooper deficiency-a history
The Journal of Nutrition
; Cardiovascular Disease from Copper Deficiency-A History1 ABSTRACT Although the nutritional essentiality of copper was established in 1928, a preoccupation with hematology delayed the discovery of cardiovascular disease from copper deficiency for more than a decade. Anatomical studies of several
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