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Directed Evolution: An Approach to Engineer Enzymes
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ABSTRACT Directed evolution is being used increasingly in industrial and academic laboratories to modify and improve commercially important enzymes. Laboratory evolution is thought to make its biggest contribution in explorations of non-natural functions, by allowing us to distinguish the properties nurtured by evolution. In this review we report the significant advances achieved with respect to the methods of biocatalyst improvement and some critical properties and applications of the modifi...
Related newspaper, magazine, and journal articles from HighBeam Research
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Directed Evolution: An Approach to Engineer Enzymes
Critical Reviews in Biotechnology
; ... rationally designed tyrosine aminotransferase. Protein Sci. 13(3): 763-772. [110] Rouhi, M. A. 2002. Chiral roundup. Chem Eng News. 80(23): 43-50. [111] Rui, L., Cao, L., Chen, W., Reardon, K. F., and Wood, T. K. 2004. Active site engineering of the epoxide ...
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New process lets biotechnology companies give evolution a boost Firms can refine substances found in nature for fighting disease, dirty laundry
The Milwaukee Journal Sentinel
; It's a revolution in evolution that Charles Darwin never dreamed of: Biotechnology companies are conducting high-speed evolution in test tubes to create everything from super laundry detergents to novel drugs. Called directed evolution, the process could prove one of the most important steps in
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A helping hand for Mother Nature
Chicago Sun-Times
; Scientists are harnessing the power of evolution in their laboratories to produce promising drugs and useful industrial chemicals that might never occur in nature, and they are doing it in days rather than eons. The ingenious process, which creates mutant genes and selects those with desired
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Directed evolution of enzymes: obtaining clean, efficient, and biodegradable catalysts.
Canadian Chemical News
; Abstract This brief technological report presents an overview of techniques and applications in the field of directed evolution of enzyme catalysts. These techniques allow for the creation of modified enzymes that are better adapted to many industrial contexts. Recent applications in organic
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High-speed evolution in a test tube: Biotechnology's new wave
The Topeka Capital-Journal
; The Associated Press SEATTLE -- It is a revolution in evolution Charles Darwin never dreamed of: Biotechnology companies are conducting high-speed evolution in test tubes to create everything from super laundry detergents to novel drugs. Called directed evolution, the process could prove one of the
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Directed Evolution Enzymes Enter the New Economy.(Brief Article)
Chemical Week
; ... the process in principle, but has struggled to increase the efficiency of the enzymes. Investors forgot all about that with the news that ENBC was a gene shuffling play, catapulting its stock to $20/share. Daniel Monticello, ENBC v.p./R&D, says he expects ...
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The Outlook for Protein Engineering in Crop Improvement
Plant Physiology
; In the early 1800s the population of the world was estimated to be around 1 billion. It grew to 2 billion in the 1920s and to 6 billion at the close of the last millennium. We are currently adding approximately 80 million more per year and, at this rate, the global population will increase from the
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The Immune System as a Tool for Directed Evolution
The Scientist
; | TOOLS & TECH | New method takes advantage of iterative somatic hypermutation to generate novel fluorescent proteins A team of researchers at the University of California, San Diego, has harnessed the body's ability to tweak antibody genes to drive protein evolution in the lab. The group, led
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Enzymes hit the spot: companies are harnessing nature's skills at biocatalysis in new enzymatic processes.(Biocatalysis)
Chemistry and Industry
; In brief * Enzyme catalysts are excellent at cleanly creating single enantiomer products * Chemists have become increasingly skilled at making enzymes more selective and efficient * A powerful way of doing this is by gene shuffling; DNA is cut up and rearranged * Lonza recently rewarded for greener
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Hercules Strengthens In-House Enzymes R&D.(Brief Article)
Chemical Week
; Directed Evolution is also bringing enzymatic processing to some specialty chemical companies. There's been a real revolution in industrial enzymes because of technology development, says Barry Marrs, director/corporate R&D at Hercules. It's got to the point now where even a company like
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