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Exhaled Breath Condensate pH and Childhood Asthma: Unselected Birth Cohort Study
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Rationale: Exhaled breath condensate pH (EBC-pH) may be useful noninvasive marker for evaluation of patients with asthma.
Objectives: To investigate the relationship between EBC-pH and symptoms suggestive of childhood asthma in an epidemiologic setting and examine its relation to lung function, airway hyperresponsiveness (AHR), and airway inflammation.
Methods: Within the context of a prospective population-based birth cohort, EBC was collected from 630 children at age 8 yr usin...
Related newspaper, magazine, and journal articles from HighBeam Research
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Effects of Smoking Cessation on Lung Function and Airway Inflammation in Smokers with Asthma
American Journal of Respiratory and Critical Care Medicine
; Rationale: Active smoking in asthma is associated with worsening of symptoms, accelerated decline in lung function, and impaired response to corticosteroids. Objectives: To examine the short-term effects of smoking cessation on lung function, airway inflammation, and corticosteroid responsiveness
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Bronchial CD8 Cell Infiltrate and Lung Function Decline in Asthma
American Journal of Respiratory and Critical Care Medicine
; Rationale: Patients with asthma have an accelerated decline in lung function, which can lead to irreversible airway obstruction. It is generally assumed that this is related to specific aspects of airway inflammation and/or remodeling. Objective: We investigated the prognostic significance of
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Pulmonary Surfactant, Lung Function, and Endobronchial Inflammation in Cystic Fibrosis
American Journal of Respiratory and Critical Care Medicine
; Cystic fibrosis (CF) lung disease is primarily a disease of the small airways. We hypothesized that even in patients with normal lung function, a reduced surfactant function would be present and favor small airway obstruction. Bronchoalveolar lavages from 76 patients with CF (5-31 years, median 11)
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Effect of Treatment with Dornase Alpha on Airway Inflammation in Patients with Cystic Fibrosis
American Journal of Respiratory and Critical Care Medicine
; Recombinant human deoxyribonuclease (rhDNase) has been shown to improve lung function and reduce the number of pulmonary exacerbations in patients with cystic fibrosis (CF), but its long-term effect on airway inflammation remains unknown. In this study, we used bronchoalveolar lavage (BAL) to
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Dissociation of Lung Function and Airway Inflammation in Chronic Obstructive Pulmonary Disease: Is It a Real or Statistical Phenomenon?
American Journal of Respiratory and Critical Care Medicine
; To the Editor. We read with interest the article by Lapperre and colleagues (1) wherein it is concluded that "airflow limitation, airway inflammation, and features commonly associated with asthma are separate and largely independent factors in the pathophysiology of COPD." This statement seems to
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Reduced Lung Function in Cystic Fibrosis: A Primary or Secondary Phenotype?
American Journal of Respiratory and Critical Care Medicine
; During the past decade, advances in the early assessment of cystic fibrosis (CF) lung disease have led to an improved understanding of its pathophysiology, but many questions still remain unanswered (1). The earliest airway abnormalities of focal, distal mucous plugging leading to peripheral airway
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Airway Inflammation in COPD: Friend or Foe?
American Journal of Respiratory and Critical Care Medicine
; A disease expected to rank third in prevalence and fifth for disability by 2020, with increasing mortality, morbidity, hospitalization rates, and which results in absence from work, and has high social cost, becomes a global and unsustainable social health problem if remedies are not taken soon.
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Infections and Airway Inflammation in Chronic Obstructive Pulmonary Disease Severe Exacerbations
American Journal of Respiratory and Critical Care Medicine
; Rationale: Severe exacerbations of chronic obstructive pulmonary disease (COPD) are major causes of health care costs mostly related to hospitalization. The role of infections in COPD exacerbations is controversial. Objectives: We investigated whether COPD exacerbations requiring hospitalization
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Respiratory Syncytial Virus, Airway Inflammation, and FEV^sub 1^ Decline in Patients with Chronic Obstructive Pulmonary Disease
American Journal of Respiratory and Critical Care Medicine
; Background: Respiratory syncytial virus (RSV) is increasingly recognized as an important pathogen in adults with cardiopulmonary disease. It has been associated with acute exacerbations of chronic obstructive pulmonary disease (COPD); however, it has also been detected in the lower airway in the
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An Investigation of Inhaled Ozone Dose and the Magnitude of Airway Inflammation in Healthy Adults
American Journal of Respiratory and Critical Care Medicine
; Exposure to ozone has been associated in epidemiologic and field studies with a range of health outcomes: increased daily mortality (1); impaired lung function (2-4); and inflammation and epithelial injury in recreational runners (5) and cyclists (6), as well as increased hospital admissions for
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