Mapping Quantitative Trait Loci by an Extension of the Haley-Knott Regression Method Using Estimating Equations

From: Genetics | Date: August 1, 2006| Author: Feenstra, Bjarke; Skovgaard, Ib M; Broman, Karl W | Copyright information

ABSTRACT

The Haley-Knott (HK) regression method continues to be a popular approximation to standard interval mapping (IM) of quantitative trait loci (QTL) in experimental crosses. The HK method is favored for its dramatic reduction in computation time compared to the IM method, something that is particularly important in simultaneous searches for multiple interacting QTL. While the HK method often approximates the IM method well in estimating QTL effects and in power to detect QTL, it ...

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