The RAD6/BRE1 Histone Modification Pathway in Saccharomyces Confers Radiation Resistance Through a RAD51-Dependent Process That Is Independent of RAD18

From: Genetics | Date: August 1, 2006| Author: Brown, J Martin; Spicakova, Tatiana; Williamson, Marsha S; Game, John C | Copyright information

ABSTRACT

We examine ionizing radiation (IR) sensitivity and epistasis relationships of several Saccharomyces mutants affecting post-translational modifications of histones H2B and H3. Mutants bre1Δ, lge1Δ, and rtf1Δ, defective in histone H2B lysine 123 ubiquitination, show IR sensitivity equivalent to that of the dot1Δ mutant that we reported on earlier, consistent with published findings that Dot1p requires H2B K123 ubiquitination to fully methylate histone H3 K79....

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