Chronic Idiopathic Myelofibrosis: Clinicopathologic Features, Pathogenesis, and Prognosis

From: Archives of Pathology & Laboratory Medicine | Date: August 1, 2006| Author: Ahmed, Arsalan; Chang, Chung-Che (Jeff) | Copyright information

Context.-Chronic idiopathic myelofibrosis (CIMF) is a clonal myeloproliferative disease characterized by panmyelosis with intact maturation, progressive bone marrow fibrosis, and multiorgan extramedullary hematopoiesis.

Objective.-This review article aims to summarize the recent updates regarding the clinicopathologic features, molecular pathogenesis, cytogenetic abnormalities, diagnostic criteria, new diagnostic ancillary tests, and prognostic factors of CIMF.

Data Sources.-Imp...

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