Down Syndrome with Myelodysplasia of Megakaryoblastic Lineage

Clinical Laboratory Science | July 1, 2006| | Copyright

The association between Down syndrome and acute myelogenous leukemia (AML) has been well documented.1,2,3 AML in Down syndrome is usually a specific type of megakaryoblastic leukemia (M7, AMKL).1 A myelodysplastic syndrome generally precedes this malignancy. Down syndrome patients with AMKL have a much better prognosis than other children with AML.5

A case study of a 22-month-old female with Down syndrome and myelodysplastic syndrome of a megakaryoblastic lineage is presented here. Upon admission to a pediatric hematology/oncology clinic, flow cytometry results reported a distinct population ...

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