Modified Hudson-Kreitman-Aguadé Test and Two-Dimensional Evaluation of Neutrality Tests From: Genetics | Date: July 1, 2006| Author: | Copyright Genetics Society of America Jul 2006. Provided by ProQuest LLC.Copyright information

ABSTRACT

There are a number of polymorphism-based statistical tests of neutrality, but most of them focus on either the amount or the pattern of polymorphism. In this article, a new test called the two-dimensional (2D) test is developed. This test evaluates a pair of summary statistics in a two-dimentional field. One statistic should summarize the pattern of polymorphism, while the other could be a measure of the level of polymorphism. For the latter summary statistic, the polymorphism-divergence ratio is used following the idea of the Hudson-Kreitman-Aguadé (HKA) test. To incorporate the ...

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