Plasma Aldosterone Assays: Comparison between Chemiluminescence-Based and RIA Methods Clinical Chemistry | July 1, 2006| | Copyright American Association for Clinical Chemistry Jul 2006. Provided by ProQuest LLC. (Hide copyright information) Copyright

To the Editor:

Measurement of plasma aldosterone is increasingly required in clinical practice because primary aldosteronism (PA) is the most frequent secondary cause of hypertension (1-4). Chemiluminescence-based (CL) assays are attractive alternatives to traditional RIAs for hormones such as aldosterone.

We compared aldosterone results obtained with a new CL method (Nichols Advantage) and an RIA [Sorin Biomedical Diagnostics (SBD)] in blood samples from 236 hypertensive patients. Blood samples were collected and immediately stored in separate aliquots at -20 °C until analysis. For 104 of ...

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