Drug resistance mechanisms in clinical isolates of Leishmania donovani

From: Indian Journal of Medical Research | Date: March 1, 2006| Author: Singh, Neeloo | Copyright information

Leishmania are protozoan parasites distributed worldwide. About 1.5-2.0 million cases are reported in the world annually from this disease and the death toll is estimated to be 57,000. Along with Brazil, Sudan and Bangladesh, India contributes to 90 per cent of the global burden of visceral leishmaniasis (VL). The absence of effective vaccines and vector control programmes, makes chemotherapy the most widely used tool against leishmaniasis. Chemotherapy based on pentavalent antimonials has be...

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