Quantitative Trait Loci Controlling Refractoriness to Plasmodium falciparum in Natural Anopheles gambiae Mosquitoes From a Malaria-Endemic Region in Western Kenya From: Genetics | Date: May 1, 2006| Author: Et al; Gouagna, Louis; Guda, Tom; Zhong, Daibin; Menge, David M | Copyright Genetics Society of America May 2006. Provided by ProQuest LLC.Copyright information

ABSTRACT

Natural anopheline populations exhibit much variation in ability to support malaria parasite development, but the genetic mechanisms underlying this variation are not clear. Previous studies in Mali, West Africa, identified two quantitative trait loci (QTL) in Anopheles gambiae mosquitoes that confer refractoriness (failure of oocyst development in mosquito midguts) to natural Plasmodium falciparum parasites. We hypothesize that new QTL may be involved in mosquito refractorine...

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