Human pharmacokinetic and dosimetry studies of [(18)F]FHBG: A reporter probe for imaging herpes simplex virus type-1 thymidine kinase reporter gene expression

From: The Journal of Nuclear Medicine | Date: August 1, 2001| Author: | Copyright information

9-[4-[^sup 18^F]fluoro-3-hydroxymethyl)butyl]guanine ([^sup 18^F]FHBG) has been used as a reporter probe to image expression of herpes simplex virus type-1 thymidine kinase (HSV1-tk) reporter gene in living animals. Our aim was to study the kinetics, biodistribution, stability, dosimetry, and safety of [^sup 18^F]FHBG in healthy human volunteers, preparatory to imaging patients undergoing HSV1-tk gene therapy. Methods: [^sup 18^F]FHBG was synthesized with a specific activity of 37,000-444,000 GBq/mmol and a radiochemical purity > 99%. Ten healthy volunteers consented to participate in the ...

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