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Log Normal Distribution of Cellular Uptake of Radioactivity: Implications for Biologic Responses to Radiopharmaceuticals
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It is widely recognized that radiopharmaceuticals are generally distributed nonuniformly in tissues. Such nonuniformities are observed over the entire range of spatial levels, ranging from organ to subcellular levels. The implications of nonuniform distributions of radioactivity for dosimetry, and ultimately for the biologic response of tissues containing radioactivity, have been investigated extensively. However, there is a paucity of experimental data on the distribution of cellular activit...
Related newspaper, magazine, and journal articles from HighBeam Research
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Log Normal Distribution of Cellular Uptake of Radioactivity/REPLY
The Journal of Nuclear Medicine
; TO THE EDITOR: In a recent study by Neti and Howell (l), the distribution of cellular uptake of radioactivily (^sup 210^Po-citrate) within a cell population was studied. They found that the distribution was log normal. Furthermore, they calculated how this distribution affects the
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Log Normal Distribution of Cellular Uptake of Radioactivity: Implications for Biologic Responses to Radiopharmaceuticals
The Journal of Nuclear Medicine
; It is widely recognized that radiopharmaceuticals are generally distributed nonuniformly in tissues. Such nonuniformities are observed over the entire range of spatial levels, ranging from organ to subcellular levels. The implications of nonuniform distributions of radioactivity for dosimetry, and
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Identification of Three Genes of Known Function Expressed by Alveolar Epithelial Type I Cells
American Journal of Respiratory Cell and Molecular Biology
; ... surfactant exocytosis in alveolar type ? cells in vitro and in vivo. News Physiol. Sci. 16:239-243. 4. Sartori. C., M. A. Matthay, and ... activator inhibitor 1: physiological and pathophysiological roles. News Physiol. Sci. 17:56-61. 30. Idell, S., K. K. James, E. G. Levin ...
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B Cells in Health and Disease
Mayo Clinic Proceedings
; B cells play a key role in regulating the immune system by producing antibodies, acting as antigen-presenting cells, providing support to other mononuclear cells, and contributing directly to inflammatory pathways. Accumulating evidence points to disruption of these tightly regulated processes in
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Recall Helper T Cell Response: T Helper 1 Cell-resistant Allergic Susceptibility without Biasing Uncommitted CD4 T Cells
American Journal of Respiratory and Critical Care Medicine
; Effector and memory T lymphocytes differ significantly, and there is no experimental evidence that memory cells are sufficient to render an otherwise normal individual susceptible to localized allergic inflammation. Furthermore, nothing is known about the kinetics of memory responses after
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Early induction of binucleated cells by ultraviolet A (UVA) radiation: A possible role of microfilaments
Photochemistry and Photobiology
; Early Induction of Binucleated Cells by Ultraviolet A (UVA) Radiation: A Possible Role of Microfilaments^^ ABSTRACT The effects of UVA (365 nm) radiation on the cellular distribution of F-actin and formation of binucleated cells have been studied using 3T3 Swiss albino mouse fibroblasts and V79
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Long-Term Deposition of Inhaled Antigen in Lung Resident CD11b^sup -^CD11c^sup +^ Cells
American Journal of Respiratory Cell and Molecular Biology
; In this study we report the characterization of a population of lung resident CD11b^sup -^CD11c^sup +^ cells that are able to take up inhaled antigen and retain it for extended periods of time. Ovalbumin conjugated to fluorescein-isothiocyanate (FITC-OVA) administered intranasally to mice was taken
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Perforin-independent CD8+ T-cell--mediated cytotoxicity of Alveolar epithelial cells in preferentially mediated by tumor necrosis (factor-alpha) relative insensitivity to Fas ligand
American Journal of Respiratory Cell and Molecular Biology
; CD8+ T cells appear to play an important pathophysiologic role in many inflammatory lung diseases. The primary effector function of this T-cell subset is cytolysis of virus-infected cells, and it is widely believed that there are two primary molecular mechanisms by which this occurs: the
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Epstein-Barr virus latently infected cells are selectively deleted in simulated-microgravity cultures
In Vitro Cellular & Developmental Biology
; SUMMARY Rotating-wall vessels (RWVs) allow for the cultivation of cells in simulated microgravity. Previously, we showed that the cultivation of lymphoblastoid cells in simulated microgravity results in the suppression of Epstein-Barr virus (EBV) reactivation. To determine if the suppression
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Naive and memory T cells migrate in comparable numbers through the normal rat lung: Only effector T Cells accumulate and proliferate in the lamina propria of the bronchi
American Journal of Respiratory Cell and Molecular Biology
; T cells reach the lung via the pulmonary and bronchial arteries that supply the alveolar and bronchial regions. Although these regions are differentially affected by T cell-mediated diseases, the migration of T-cell subsets in these two regions has not been studied. Naive, memory, and effector T
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