ER[beta] scientific visions translate to clinical uses

From: Climacteric | Date: June 1, 2006| Author: | Copyright information

Key words: AUTOIMMUNE DISEASES, ENDOMETRIOSIS, DEPRESSION, HYPERTENSION, ERβ AGONIST

ABSTRACT

Estrogen receptor β (ERβ) was discovered in 1995 and reported on in 1996. During the 10 years following this event, our understanding of estrogen signaling has changed remarkably. We now know that estradiol, the major endogenous activator of ER, is non-selective for the two receptors, and that ERα and ERβ are, in many contexts, antagonistic against one another, an example of a yin/yang relationship, perhaps nature's way to accomplish subtle regulatory changes of estrogen ...

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