Model of Chromosome Motility in Drosophila Embryos: Adaptation of a General Mechanism for Rapid Mitosis From: Biophysical Journal | Date: June 1, 2006| Author: Mogilner, A; Scholey, J M; Sharp, D J; Civelekoglu-Scholey, G | Copyright Biophysical Society Jun 1, 2006. Provided by ProQuest LLC.Copyright information

ABSTRACT

During mitosis, ensembles of dynamic MTs and motors exert forces that coordinate chromosome segregation. Typically, chromosomes align at the metaphase spindle equator where they oscillate along the pole-pole axis before disjoining and moving poleward during anaphase A, but spindles in different cell types display differences in MT dynamicity, in the amplitude of chromosome oscillations and in rates of chromatid-to-pole motion. Drosophila embryonic mitotic spindles, for example...

Related newspaper, magazine, and journal articles from HighBeam Research

	+TIPs and Microtubule Regulation. The Beginning of the Plus End in Plants1 Plant Physiology ; ... tubule and by an array of regulatory proteins termed MAPs (MT-associated proteins). The inherent dynamics, or dynamic ... Shaw et al., 2003). MT dynamics are also regulated by MAPs. Many MAPs bind to the sides of MTs and stabilize, destabilize ...
	Model of Chromosome Motility in Drosophila Embryos: Adaptation of a General Mechanism for Rapid Mitosis Biophysical Journal ; ABSTRACT During mitosis, ensembles of dynamic MTs and motors exert forces that coordinate chromosome segregation. Typically, chromosomes align at the metaphase spindle equator where they oscillate along the pole-pole axis before disjoining and moving poleward during anaphase A, but spindles in
	A simple, mechanistic model for directional instability during mitotic chromosome movements Biophysical Journal ; ABSTRACT During mitosis, chromosomes become attached to microtubules that emanate from the two spindle poles. Thereafter, a chromosome moves along these microtubule "tracks" as it executes a series of movements that bring it to the spindle equator. After the onset of anaphase, the sister chromatids
	Regulation of membrane transport by rab GTPases Critical Reviews in Biochemistry and Molecular Biology ; ABSTRACT: Membrane flow through the cell is a highly dynamic process in which intracellular compartments communicate via tubulo-vesicular structures shuttling cargo molecules to their destinations. Transport carriers are formed at a donor compartment and navigate through the cytoplasm to the target
	Microtubule treadmilling in vitro investigated by fluorescence speckle and confocal microscopy Biophysical Journal ; ... from the lattice and rapidly dissociate (Tran et al., 1997). Tubulin-- GDP dissociation ... vinblastine. Biochemistry. 32:1285-1293. Tran, P. T., P. Joshi, and E. D. Salmon. 1997a ... Struct. Biol. 118: 107-118. [Reference] Tran, P. T., R. A. Walker, and E. D. Salmon ...
	Regulation of actin dynamics in rapidly moving cells: A quantitative analysis Biophysical Journal ; ABSTRACT We develop a mathematical model that describes key details of actin dynamics in protrusion associated with cell motility. The model is based on the dendritic-nucleation hypothesis for lamellipodial protrusion in nonmuscle cells such as keratocytes. We consider a set of partial differential
	The Arabidopsis AAA ATPase SKD1 Is Involved in Multivesicular Endosome Function and Interacts with Its Positive Regulator LYST-INTERACTING PROTEIN5(W) Plant Cell ; In yeast and mammals, the AAA ATPase Vps4p/SKD1 (for Vacuolar protein sorting 4/SUPPRESSOR OF K+ TRANSPORT GROWTH DEFECT1) is required for the endosomal sorting of secretory and endocytic cargo. We identified a VPS4/SKD1 homolog in Arabidopsis thaliana, which localizes to the cytoplasm and to
	A force balance model of early spindle pole separation in Drosophila embryos Biophysical Journal ; ABSTRACT The formation and function of the mitotic spindle depends upon force generation by multiple molecular motors and by the dynamics of microtubules, but how these force-generating mechanisms relate to one another is unclear. To address this issue we have modeled the separation of spindle
	The Integral Membrane Protein Pom34p Functionally Links Nucleoporin Subcomplexes Genetics ; ABSTRACT Here we have examined the function of Pom34p, a novel membrane protein in Saccharomyces cerevisiae, localized to nuclear pore complexes (NPCs). Membrane topology analysis revealed that Pom34p is a double-pass transmembrane protein with both the amino (N) and carboxy (C) termini positioned
	Analysis of the small GTPase gene superfamily of Arabidopsis Plant Physiology ; ... the C2 domain as a Ca"-dependent electrostatic switch. Neuron 18: 133-142 Simons K, Zerial M (1993) Rab proteins and the road maps for intracellular transport. Neuron 11: 789-799 Simonsen A, Lippe R, Christoforidis S, Gaullier JM, Brech A, Callaghan J, Toh ...

See all results.