SepB^sup CTF4^ Is Required for the Formation of DNA-Damage-Induced UvsC^sup RAD51^ Foci in Aspergillus nidulans From: Genetics | Date: April 1, 2005| Author: | Copyright Genetics Society of America Apr 2005. Provided by ProQuest LLC.Copyright information

ABSTRACT

SepB is an essential, conserved protein required for chromosomal DNA metabolism in Aspergillus nidulans. Homologs of SepB include yeast Ctf4p and human hAnd-1. Molecular and bioinformatic characterization of these proteins suggests that they act as molecular scaffolds. Furthermore, recent observations implicate the yeast family members in lagging-strand replication and the establishment of sister-chromatid cohesion. Here, we demonstrate that SepB functions in the A. nidulans DNA damage response. In particular, analysis of double mutants reveals that SepB is a member of the Uvs^sup ...

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