Allele Frequency Distribution Under Recurrent Selective Sweeps

From: Genetics | Date: March 1, 2006| Author: Kim, Yuseob | Copyright information

ABSTRACT

The allele frequency of a neutral variant in a population is pushed either upward or downward by directional selection on a linked beneficial mutation ("selective sweeps"). DNA sequences sampled after the fixation of the beneficial allele thus contain an excess of rare neutral alleles. This study investigates the allele frequency distribution under selective sweep models using analytic approximation and simulation. First, given a single selective sweep at a fixed time, I deriv...

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