Estimating the "Effective Number of Codons": The Wright Way of Determining Codon Homozygosity Leads to Superior Estimates

From: Genetics | Date: February 1, 2006| Author: Fuglsang, Anders | Copyright information

ABSTRACT

In 1990, Frank Wright introduced a method for measuring synonymous codon usage bias in a gene by estimation of the "effective number of codons," N^sub c^. Several attempts have been made recently to improve Wright's estimate of N^sub c^, but the methods that work in cases where a gene encodes a protein not containing all amino acids with degenerate codons have not been tested against each other. In this article I derive five new estimators of N^sub c^ and test them together wi...

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