Flexibility in a Gene Network Affecting a Simple Behavior in Drosophila melanogaster

From: Genetics | Date: March 1, 2005| Author: Greenspan, Ralph J; van Swinderen, Bruno | Copyright information

ABSTRACT

Gene interactions are emerging as central to understanding the realization of any phenotype. To probe the flexibility of interactions in a defined gene network, we isolated a set of 16 interacting genes in Drosophila, on the basis of their alteration of a quantitative behavioral phenotype-the loss of coordination in a temperature-sensitive allele of Syntaxin1A. The interactions inter se of this set of genes were then assayed in the presence and in the absence of the original S...

Read all of this article with a FREE trial to HighBeam Research

Related newspaper, magazine, and journal articles from HighBeam Research

Epistasis for Fitness-Related Quantitative Traits in Arabidopsis thaliana Grown in the Field and in the Greenhouse
Genetics ; ... greenhouse). The seed length G X effect maps close to a locus involved in an epistatic ... interaction 1 involves one locus that maps to 1-117.8 while field seed-length interaction 2 involves one locus that maps to 1-117.2. Most of the significant epistatic ...
Flexibility in a Gene Network Affecting a Simple Behavior in Drosophila melanogaster
Genetics ; ABSTRACT Gene interactions are emerging as central to understanding the realization of any phenotype. To probe the flexibility of interactions in a defined gene network, we isolated a set of 16 interacting genes in Drosophila, on the basis of their alteration of a quantitative behavioral
Effect of Varying Epistasis on the Evolution of Recombination
Genetics ; ABSTRACT Whether recombination decelerates or accelerates a population's response to selection depends, at least in part, on how fitness-determining loci interact. Realistically, all genomes likely contain fitness interactions both with positive and with negative epistasis. Therefore, it is crucial
Epistasis Between Calpain 1 and Its Inhibitor Calpastatin Within Breeds of Cattle
Genetics ; ABSTRACT The calpain gene family and its inhibitors have diverse effects, many related to protein turnover, which appear to affect a range of phenotypes such as diabetes, exercise-induced muscle injury, and pathological events associated with degenerative neural diseases in humans, fertility,
Evolution Can Favor Antagonistic Epistasis
Genetics ; ABSTRACT The accumulation of deleterious mutations plays a major role in evolution, and key to this are the interactions between their fitness effects, known as epistasis. Whether mutations tend to interact synergistically (with multiple mutations being more deleterious than would be expected from
Genetic Expectations of Quantitative Trait Loci Main and Interaction Effects Obtained With the Triple Testcross Design and Their Relevance for the Analysis of Heterosis
Genetics ; ABSTRACT Interpretation of experimental results from quantitative trait loci (QTL) mapping studies on the predominant type of gene action can be severely affected by the choice of statistical model, experimental design, and provision of epistasis. In this study, we derive quantitative genetic
Triple testcross analysis to detect epistasis in maize.
Crop Science ; Maize Breeders have successfully exploited heterosis for grain yield through the crossing of inbred lines to develop desirable hybrids. The nature of gene action involved in expression of heterosis for grain yield of elite maize hybrids, however, remains unresolved. Information on genetic
Epistasis for vegetative and reproductive traits in peanut.
Crop Science ; Many traits of economic importance in peanut, a self pollinated annual legume crop, are quantitatively inherited. The exploitation of genetic variability (additive variation) of these traits through hybridization, inbreeding, and selection is the primary focus of most peanut improvement programs. A
Epistasis in Monkeyflowers
Genetics ; ABSTRACT Epistasis contributes significantly to intrapopulation variation in floral morphology, development time, and male fitness components of Mimulus guttatus. This is demonstrated with a replicated line-cross experiment involving slightly over 7000 plants. The line-cross methodology is based on
Quantitative trait locus analysis of stalk strength in four maize populations. (Crop Breeding, Genetics & Cytology).
Crop Science ; ... version 3.0b was used to construct linkage maps (Lander et al., 1987; Lincoln et al., 1992 ... Jampatong et al. (2002) for individual linkage maps. Only one region on chromosome 3 contained ... for constructing primary genetic linkage maps of experimental and natural populations ...