Rapid Evolution Through Gene Duplication and Subfunctionalization of the Testes-Specific [alpha]4 Proteasome Subunits in Drosophila From: Genetics | Date: November 1, 2004| Author: Singh, Rama S; Torgerson, Dara G | Copyright Genetics Society of America Nov 2004. Provided by ProQuest LLC.Copyright information

ABSTRACT

Gene duplication is an important mechanism for acquiring new genes and creating genetic novelty in organisms. Evidence suggests that duplicated genes are retained at a much higher rate than originally thought and that functional divergence of gene copies is a major factor promoting their retention in the genome. We find that two Drosophila testes-specific α4 proteasome subunit genes (α4-t1 and α4-t2) have a higher polymorphism within species and are significantl...

Related newspaper, magazine, and journal articles from HighBeam Research

	Rapid Evolution Through Gene Duplication and Subfunctionalization of the Testes-Specific [alpha]4 Proteasome Subunits in Drosophila Genetics ; ABSTRACT Gene duplication is an important mechanism for acquiring new genes and creating genetic novelty in organisms. Evidence suggests that duplicated genes are retained at a much higher rate than originally thought and that functional divergence of gene copies is a major factor promoting their
	Evolutionary Dynamics of the DNA-Binding Domains in Putative R2R3-MYB Genes Identified from Rice Subspecies indica and japonica Genomes1[w] Plant Physiology ; The molecular evolution of the R2R3-MYB gene family is of great interest because it is one of the most important transcription factor gene families in the plant kingdom. Comparative analyses of a gene family may reveal important adaptive changes at the protein level and thereby provide insights
	Evolution of Mammalian Chitinase(-Like) Members of Family 18 Glycosyl Hydrolases Genetics ; ABSTRACT Family 18 of glycosyl hydrolases encompasses chitinases and so-called chi-lectins lacking enzymatic activity due to amino acid substitutions in their active site. Both types of proteins widely occur in mammals although these organisms lack endogenous chitin. Their physiological function(s)
	Adaptive Functional Divergence Among Triplicated [alpha]-Globin Genes in Rodents Genetics ; ABSTRACT The functional divergence of duplicated genes is thought to play an important role in the evolution of new developmental and physiological pathways, but the role of positive selection in driving this process remains controversial. The objective of this study was to test whether amino acid
	Reconstructing the Evolutionary History of Paralogous APETALA1/FRUITFULL-Like Genes in Grasses (Poaceae) Genetics ; ABSTRACT Gene duplication is an important mechanism for the generation of evolutionary novelty. Paralogous genes that are not silenced may evolve new functions (neofunctionalization) that will alter the developmental outcome of preexisting genetic pathways, partition ancestral functions
	A Genomics Approach to the Detection of Positive Selection in Cattle: Adaptive Evolution of the T-Cell and Natural Killer Cell-Surface Protein CD2 Genetics ; ABSTRACT The detection of adaptive evolution at the molecular level is of interest not only as an insight into the process of evolution but also because of its functional implications for genes of interest. Here, we present the first genomics approach to detecting positive selection operating on
	Accuracy and Power of Statistical Methods for Detecting Adaptive Evolution in Protein Coding Sequences and for Identifying Positively Selected Sites Genetics ; ABSTRACT The parsimony method of SUZUKI and GOJOBORI (1999) and the maximum likelihood method developed from the work of NIELSEN and YANG (1998) are two widely used methods for detecting positive selection in homologous protein coding sequences. Both methods consider an excess of nonsynonymous
	Detecting Amino Acid Sites Under Positive Selection and Purifying Selection Genetics ; ABSTRACT An excess of nonsynonymous over synonymous substitution at individual amino acid sites is an important indicator that positive selection has affected the evolution of a protein between the extant sequences under study and their most recent common ancestor. Several methods exist to detect
	Accelerated Rate of Gene Gain and Loss in Primates Genetics ; ABSTRACT The molecular changes responsible for the evolution of modern humans have primarily been discussed in terms of individual nucleotide substitutions in regulatory or protein coding sequences. However, rates of nucleotide substitution are slowed in primates, and thus humans and chimpanzees
	Divergence of the Dof Gene Families in Poplar, Arabidopsis, and Rice Suggests Multiple Modes of Gene Evolution after Duplication1[W] Plant Physiology ; It is widely accepted that gene duplication is a primary source of genetic novelty. However, the evolutionary fate of duplicated genes remains largely unresolved. The classical Ohno's Duplication-Retention-Non/Neofunctionalization theory, and the recently proposed alternatives such as

See all results.