Human Endogenous Retroviral Elements as Indicators of Ectopic Recombination Events in the Primate Genome

From: Genetics | Date: November 1, 2005| Author: | Copyright information

ABSTRACT

HERV elements make up a significant fraction of the human genome and, as interspersed repetitive elements, have the capacity to provide substrates for ectopic recombination and gene conversion events. To understand the extent to which these events occur and gain further insight into the complex evolutionary history of these elements in our genome, we undertook a phylogenetic study of the long terminal repeat sequences of 15 HERV-K(HML-2) elements in various primate species. This family of human endogenous retroviruses first entered the primate genome between 35 and 45 million years ...

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