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Mutation Rates, Spectra and Hotspots in Mismatch Repair-Deficient Caenorhabditis elegans
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ABSTRACT
Although it is clear that postreplicative DNA mismatch repair (MMR) plays a critical role in maintaining genomic stability in nearly all forms of life surveyed, much remains to be understood about the genomewide impact of MMR on spontaneous mutation processes and the extent to which MMR-deficient mutation patterns vary among species. We analyzed spontaneous mutation processes across multiple genomic regions using two sets of mismatch repair-deficient (msh-2 and msh-6) Caenorhabditis elegans mutation-accumulation (MA) lines and compared our observations to mutation spectra in a set of ...
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Spontaneous Mutations in Diploid Saccharomyces cerevisiae: More Beneficial Than Expected
; ...the yeast, Saccharomyces cerevisiae. The MA lines exhibited a significant reduction in mean...and substantially reduce the number of MA lines that are deinformative. ZEYL and DEVISSER...eukaryotes. Second, we used many more MA lines and accumulated mutations for more generations...
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Genomic Mutation in Lines of Arabidopsis thaliana Exposed to Ultraviolet-B Radiation
; ...small but significant rate of mutation for MA lines propagated under supplemental UV-B exposure...deleterious mutational load, fitness assays of MA lines may be limited in their power to detect...repairdeficient mutants, by direct sequencing of MA lines to detect all mutations and by ...
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Increase of the Spontaneous Mutation Rate in a Long-Term Experiment With Drosophila melanogaster
; ...GARCA-DORADO 2002) consisted of 200 full-sib MA lines and a large control population (referred...we report the results from a new set of MA lines (MA2) derived from a single line from...mutation accumulation on the viability of the MA lines and on the rates of fitness and ...
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The Rate and Spectrum of Microsatellite Mutation in Caenorhabditis elegans and Daphnia pulex
; ...use of long-term mutation-accumulation (MA) lines to provide robust estimates of the rates...Mutation-accumulation lines: C. elegans and D. pulex MA lines were propagated using single, randomly...design and maintenance of the C. elegans MA lines is described in Vassilieva and Lynch...
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Gene Action of New Mutations in Arabidopsis thaliana
; ...and the anticipated subtlety of effects limited the number of MA lines included in this study to 8. Each MA line was selfed and reciprocally...mutations when expressed in homozygous state. Alternatively, MA lines may be propagated clonally, and, in this case, mutations are...
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The Relative Roles of Three DNA Repair Pathways in Preventing Caenorhabditis elegans Mutation Accumulation
; ...regions. In this study we examine mutation processes in base excision repair-deficient (nth-1) and nucleotide excision...xpa-1) Caenorhabditis elegans mutation-accumulation (MA) lines across 24 regions of the genome and compare our observations...repair-deficient (msh-2 and msh-6) and wild-type (N2) ...
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Genotype-Environment Interactions of Spontaneous Mutations for Vegetative Fitness in the Human Pathogenic Fungus Cryptococcus neoformans
; ...neoformans. Eight mutation accumulation (MA) lines were established from a single clone on...200, 400, and 600 for each of the 16 MA lines were stored and assayed for vegetative...spontaneous mutations. Overall, clones from MA lines maintained at 37 showed less decline in...
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distributor company information (3).
; ...Hartford, CT 06106 860-951-1644 800-726-2389 Fax: 860-541-6303 Richard Shane pres., Arnold Haspel vp Areas Served:CT, Western MA Lines Distributed:APM AccuPly Underlayment, Astor Blades, ALM Carpet Binding/Machines, Crain Co. Tools, Duo-Fast Staples/Machines...
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Low Impact of Germline Transposition on the Rate of Mildly Deleterious Mutation in Caenorhabditis elegans
; ...thought to be central to the evolution of many basic features of natural populations. We propagated mutation-accumulation (MA) lines of two RNAi-deficient strains of Caenorhabditis elegans that exhibit germline transposition. We show here that the impact of...
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Fiber-optic sensors spread out
; ...test, nitrogen gas flowed through the inert catalyst and served as a heal transfer medium. The organization ran only 16 4-20 mA lines from the control room to the signal conditioner, and so monitored only 16 of the 37 sensors in the probe. Five reference thermocouples...
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