Haploidy, Diploidy and Evolution of Antifungal Drug Resistance in Saccharomyces cerevisiae

From: Genetics | Date: December 1, 2004| Author: | Copyright information

ABSTRACT

We tested the hypothesis that the time course of the evolution of antifungal drug resistance depends on the ploidy of the fungus. The experiments were designed to measure the initial response to the selection imposed by the antifungal drug fluconazole up to and including the fixation of the first resistance mutation in populations of Saccharomyces cerevisiae. Under conditions of low drug concentration, mutations in the genes PDR1 and PDR3, which regulate the ABC transporters implicated in resistance to fluconazole, are favored. In this environment, diploid populations of defined size ...

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