Meiotic Chromosome Synapsis in Yeast Can Occur Without Spo11-Induced DNA Double-Strand Breaks

From: Genetics | Date: October 1, 2004| Author: | Copyright information

ABSTRACT

Proper chromosome segregation and formation of viable gametes depend on synapsis and recombination between homologous chromosomes during meiosis. Previous reports have shown that the synaptic structures, the synaptonemal complexes (SCs), do not occur in yeast cells with the SPO11 gene removed. The Spo11 enzyme makes double-strand breaks (DSBs) in the DNA and thereby initiates recombination. The view has thus developed that synapsis in yeast strictly depends on the initiation of recombination. Synapsis in some other species (Drosophila melanogaster and Caenorhabditis elegans) is ...

Read all of this article with a FREE trial to HighBeam Research

Related newspaper, magazine, and trade journal articles from HighBeam Research

(Including press releases, facts, information, and biographies)

Suppressor Analysis of a Histone Defect Identifies a New Function for the Hda1 Complex in Chromosome Segregation
; ...shown to cause chromosome segregation defects, including...ploidy and chromosome segregation, we performed...for normal chromosome segregation and cell cycle...participation in chromosome segregation. Moreover...function in chromosome segregation. DURING ...
The Evolution of Sex and Recombination in Response to Abiotic or Coevolutionary Fluctuations in Epistasis
; ...widespread phenomena of sex and recombination. One hypothesis is that host-parasite interactions favor sex and recombination because they favor the production...analyze the evolution of sex and recombination when the temporal fluctuations...
Maternal Phosphatase Inhibitor-2 Is Required for Proper Chromosome Segregation and Mitotic Synchrony During Drosophila Embryogenesis
; ...Embryos derived from I-2 mutant mothers show faulty chromosome segregation and loss of mitotic synchrony in cleavage-stage embryos...hatch rate. We propose that I-2 is required for proper chromosome segregation during Drosophila embryogenesis through the coordinated...
Chromosome segregation in fertilized eggs from triploid Pacific oysters, Crassostrea gigas (Thunberg), following inhibition of polar body 1.
; ...of blocking PB 1 on subsequent chromosome segregation in diploid eggs revealed a variety...blocking PB1 greatly changed the chromosome segregation in triploid eggs. The objectives...different pairs of parents. To study chromosome segregation, samples of developing zygotes...
mei-38 Is Required for Chromosome Segregation During Meiosis in Drosophila Females
; ABSTRACT Meiotic chromosome segregation occurs in Drosophila...chromosome complement. Proper chromosome segregation during meiosis is crucial...disorganized. In contrast, chromosome segregation at meiosis II and in...
Statistical Power Analysis of Neutrality Tests Under Demographic Expansions, Contractions and Bottlenecks With Recombination
; ...study the effects of demography and recombination upon neutrality tests by analyzing...incorrect estimates of the rates of recombination when testing for neutrality. We show...strongly affected by misestimations of recombination, so they should not be used when recombination...
Pronounced Differences of Recombination Activity at the Sex Determination Locus of the Honeybee, a Locus Under Strong Balancing Selection
; ABSTRACT Recombination decreases the association of linked...populations. When coupled with selection, recombination may relax potential conflict among...in research on the evolution of recombination. The sex determination locus (SDL...
Effect of Varying Epistasis on the Evolution of Recombination
; ABSTRACT Whether recombination decelerates or accelerates a population...the potential beneficial effects of recombination with negative epistasis prevail over the detrimental effects of recombination with positive epistasis. Here, we...
Effects of Recombination on Hitchhiking Diversity in the Brassica Self-incompatibility Locus Complex
; ...this region the "S-locus complex." Recombination in the S-locus complex is considered...rapa and B. oleracea suggested that recombination reduced the nucleotide diversity in...domain, of SRK have also experienced recombination. Recombination may reduce hitchhiking...
Recombination between a crown rust resistance locus and an interchange breakpoint in hexaploid oat.
; ...genotypes differ by chromosome interchange differences...In such heterozygotes, recombination may occur between homologous...on considerations of chromosome segregation and differential viability...addition to consideration of chromosome segregation, linkage...indicate changes in ...