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Internalization of sst^sub 2^, sst^sub 3^, and sst^sub 5^ Receptors: Effects of Somatostatin Agonists and Antagonists
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The uptake of radiolabeled somatostatin analogs by tumor cells through receptor-mediated internalization is a critical process for the in vivo targeting of tumoral somatostatin receptors. In the present study, the somatostatin receptor internalization induced by a variety of somatostatin analogs was measured with new immunocytochemical methods that allow characterization of trafficking of the somatostatin receptor subtype 2 (sst^sub 2^), somatostatin receptor subtype 3 (sst^sub 3^), and somat...
