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Gluc-Lys([^sup 18^F]FP)-TOCA PET in Patients with SSTR-Positive Tumors: Biodistribution and Diagnostic Evaluation Compared with [^sup 111^In]DTPA-Octreotide
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A recently developed ^sup 18^F-labeled PET tracer for somatostatin receptor (sstr) imaging, N^sup α^-(1-deoxy-D-fructosyl)-N^sup ε^-(2-[^sup 18^F]fluoropropionyl)-Lys^sup 0^-Tyr^sup 3^-octreotate (Gluc-Lys([^sup 18^F]FP)-TOCA), was evaluated in patients with sstr-positive tumors by assessing the pharmacokinetics, biodistribution, and diagnostic performance in comparison with [^sup 111^ln]DTPA-octreotide. Methods: Twenty-five patients with different sstr-positive tumors were included in the study and were injected with 105 ± 50 MBq Gluc-Lys([^sup 18^F]FP)-TOCA. PET was performed up ...
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Pharmacokinetics and Biodistribution of ^sup 111^In- and ^sup 177^Lu-Labeled J591 Antibody Specific for Prostate-Specific Membrane Antigen: Prediction of ^sup 90^Y-J591 Radiation Dosimetry Based on ^sup 111^In or ^sup 177^Lu?
; ^sup 111^In-Labeled antibodies and peptides have...used as chemical and biologic surrogates for ^sup 90^Y-labeled therapeutic agents. However, recent...significant differences in biodistribution between ^sup 111^In- and ^sup 90^Y-labeled agents. Yttrium...
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Effects of Intracellular and Extracellular Concentrations of Ca^sup 2+^, K+, and Cl- on the Na+-Dependent Mg^sup 2+^ Efflux in Rat Ventricular Myocytes
; ABSTRACT Intracellular Mg^sup 2+^ concentration ([Mg^sup 2+^]^sub i^) was measured in rat ventricular myocytes with...indicator furaptra (25C). After the myocytes were loaded with Mg^sup 2+^, the initial rate of decrease in [Mg^sup 2+^]^sub i^ (initial...
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An intrapatient comparison of ^sup 99m^Tc-EDDA/ HYNIC-TOC with ^sup 111^In-DTPA-Octreotide for diagnosis of somatostatin receptor-expressing tumors
; ...achieved higher tumor-to-normal tissue ratios than ^sup 111^In-OCT. Conclusion: This study revealed a higher sensitivity of ^sup 99m^Tc-TOC as compared with ^sup 111^In-OCT as an imaging agent for the localization...SSTR-expressing tumors. To avoid false-positive findings with ^sup ...
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Processing of Generator-Produced ^sup 68^Ga for Medical Application
; The ^sup 68^Ge/^sup 68^Ga generator provides an excellent source of positron-emitting ^sup 68^Ga. However, newly available "ionic" ^sup 68^Ge/^sup 68^Ga radionuclide generators are not necessarily optimized for the synthesis of ^sup 68^Ga-labeled...
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Low-Affinity Na^sup +^ Uptake in the Halophyte Suaeda maritima1[C][W][OA]
; Na^sup +^ uptake by plant roots has largely been explored using species that accumulate little Na^sup +^ into their shoots. By way of contrast, Nathe...its leaves. Here we report that cAMP and Ca^sup 2+^ (blockers of nonselective cation channels...
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^sup 99m^Tc-N-DBODC5, a New Myocardial Perfusion Imaging Agent with Rapid Liver Clearance: Comparison with ^sup 99m^Tc-Sestamibi and ^sup 99m^Tc-Tetrofosmin in Rats
; ^sup 99m^Tc-[bis (dimethoxypropylphosphinoethyl)-ethoxyethylamine (PNP5...myocardial uptake and clearance kinetics and organ biodistribution of ^sup 99m^Tc-N-DBODC5 with ^sup 99m^Tc-sestamibi and ^sup 99m^Tc-tetrofosmin. Methods: Seventy-five...
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Comparison of ^sup 123^I and ^sup 131^I for Whole-Body Imaging in Thyroid Cancer
; We compared the diagnostic sensitivities of ^sup 123^I and ^sup 131^I whole-body imaging in differentiated thyroid cancer...thyroidectomized patients (3 previously treated with ^sup 131^I) were studied. After a period of thyroid hormone...
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Arabidopsis HMA2, a Divalent Heavy Metal-Transporting P^sub IB^-Type ATPase, Is Involved in Cytoplasmic Zn^sup 2+^ Homeostasis1
; P^sup IB^-type ATPases transport heavy metal ions (Cu^sup +^, Cu^sup 2+^, Zn^sup 2+^, Cd^sup 2+^, Co^sup 2+^, etc.) across biological membranes. Several members of this subfamily are present in plants. Higher plants are the only eukaryotes where putative...
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Skeletal PET with ^sup 18^F-Fluoride: Applying New Technology to an Old Tracer*
; Although ^sup 18^F-labeled NaF was the first widely used...fell into disuse after the introduction of ^sup 99m^Tc-labeled bone-imaging agents. Recent comparative studies have demonstrated that ^sup 18^F-fluoride PET is more accurate than ^sup...
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Treatment with ^sup 177^Lu-DOTATOC of Patients with Relapse of Neuroendocrine Tumors After Treatment with ^sup 90^Y-DOTATOC
; Therapy with [^sup 90^Y-DOTA^sup 0^, Tyr^sup 3^]-octreotide (DOTATOC, where DOTA = tetraazacyclododecane tetraacetic acid and TOC = D-Phe-c(Cys-Tyr-D-Trp-Lys-Thr-Cys)-Thr(ol)) is established for the treatment of metastatic neuroendocrine tumors. Nevertheless...
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