Effect of Plasmodium falciparum Parasitemia on Erythrocyte Zinc Protoporphyrin

From: Clinical Chemistry | Date: April 1, 2006| Author: Black, Robert E; Sazawal, Sunil; Sullivan, David J Jr; Tripathi, Abhai K; Hiremath, Girish S | Copyright information

To the Editor:

In regions holoendemic for malaria, both iron deficiency and asymptomatic malaria parasitemia are common (1). Measurements of transferrin receptor and erythrocyte zinc protoporphyrin IX (ZnPPIX) concentrations have been suggested as screening tools to detect iron deficiency (1,2). Chronic iron-deficient erythropoiesis leads to a relative increase in the insertion of zinc rather than iron into erythrocyte PPIX.

Anemia of chronic disease and hyperbilirubinemia can d...

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