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Re: Late-Onset Neutropenia With Clozapine/Reply: Late-Onset Neutropenia With Clozapine
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Dear Editor:
The recent case report by Thompson and colleagues on late-onset neutropenia with clozapine raises a few questions (1). The authors do not define mild neutropenia and incorrectly call an absolute neutrophil count (ANC) of 1.86 x 109/L mild neutropenia. The most accepted definition of mild neutropenia is an ANC of 1.0 to 1.5 x 109/L (2). Further, the authors do not elaborate on the role of valproic acid in the presentation of clozapine-induced neutropenia. Valproic acid is i...
Related newspaper, magazine, and journal articles from HighBeam Research
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Re: Late-Onset Neutropenia With Clozapine/Reply: Late-Onset Neutropenia With Clozapine
Canadian Journal of Psychiatry
; Dear Editor: The recent case report by Thompson and colleagues on late-onset neutropenia with clozapine raises a few questions (1). The authors do not define mild neutropenia and incorrectly call an absolute neutrophil count (ANC) of 1.86 x 109/L mild neutropenia. The most accepted definition of
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Valproic acid.(Drugs, Pregnancy, And Lactation)
Family Practice News
; For more than 20 years, the risk of neural tube defects (NTDs) associated with first-trimester exposure to valproic acid has been well known: The estimated risk is 2%, about 10- to 20-fold higher than the baseline risk. With more widespread use of valproic acid, partly due to increasing use of the
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Valproic acid.(DRUGS, PREGNANCY, AND LACTATION)
Internal Medicine News
; For more than 20 years, the risk of neural tube defects (NTDs) associated with first-trimester exposure to valproic acid has been well known: The estimated risk is 2%, about 10- to 20-fold higher than the baseline risk. With more widespread use of valproic acid, partly due to increasing use of the
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Case files of the Children's Hospital of Michigan Regional Poison Control Center: the use of carnitine for the management of acute valproic acid toxicity.(Toxicology Case Files)(Case study)
Journal of Medical Toxicology
; CASE PRESENTATION A 28-year-old African-American male was found unresponsive outside of his girlfriend's house around 7 o'clock in the morning. He spent the night at the girlfriend's house and was last witnessed to be awake about 12 hours earlier. The girlfriend and her family were unable to awaken
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Valproic Acid / Divalproex
Chicago Sun-Times
; What is it? Valproic acid (val-PRO-ic acid), sold under the trade name Depakote, and divalproex (dye-VAL-pro-ex), sold under the trade names Dalpro, Depakene and Myproic Acid, are oral anti-convulsant medications used by themselves or with other drugs to treat epilepsy. Valproic acid also is being
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Drugs, pregnancy, and lactation: valproic acid.(Obstetrics)
OB GYN News
; For more than 20 years, the risk of neural tube defects (NTDs) associated with first-trimester exposure to valproic acid has been well known: The estimated risk is 2%, about 10- to 20-fold higher than the baseline risk. With more widespread use of valproic acid, partly due to increasing use of the
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Bullous Lesion Marks Valproic Acid Poisoning.
Pediatric News
; NEW ORLEANS -- A healthy 4-year-old exhibited symptoms of valproic acid poisoning concurrently with ecchymotic skin lesions, some of which became bullous, Dr. Elizabeth A. Christ reported in a poster presentation at the Southern regional meeting of the American Federation for Medical Research.
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Reversible Neutrophil Abnormalities Related to Supratherapeutic Valproic Acid Levels
Mayo Clinic Proceedings
; A 58-year-old man with seizures who was taking valproic acid (1000 mg in the morning and 1500 mg at night during the past 6 months) had anemia (hemoglobin level, 11.0 g/dL [to convert to g/L, multiply by 10 leukopenia (white blood cell count, 2.8 10^sup 9^; 73% neutrophils; 14% monocytes; 13%
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Valproic acid-induced eosinophilic pleural effusion.(Case Report)
Southern Medical Journal
; Abstract: Valproic acid is a carboxylic acid used for the treatment of both seizure and mood disorders. Its association with pleural fluid eosinophilia has been reported once in the English language literature. We present another case of valproic acid-induced pleural fluid eosinophilia associated
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Greater risk of birth defects with valproic acid: defect rate is 2-3.5 times higher with valproic acid than with newer AEDs.(News)
OB GYN News
; Physicians seeing young girls and women with epilepsy now have strong reason to ensure the prescription of newer anti-epileptic drugs whenever possible. New data suggest that older anti-epileptic drugs (AEDs) particularly valproic acid, when taken during pregnancy, are associated with a high risk
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