CLOCK GENES OF MAMMALIAN CELLS: PRACTICAL IMPLICATIONS IN TISSUE CULTURE From: In Vitro Cellular & Developmental Biology | Date: November 1, 2005| Author: Kaeffer, Bertrand; Pardini, Lissia | Copyright Society for In Vitro Biology Nov/Dec 2005. Provided by ProQuest LLC.Copyright information

SUMMARY

The clock genes family is expressed by all the somatic cells driving central and peripheral circadian rhythms through transcription/translation feedback loops. The circadian clock provides a local time for a cell and a way to integrate the normal environmental changes to smoothly adapt the cellular machinery to new conditions. The central circadian rhythm is retained in primary cultures by neurons of the suprachiasmatie nuclei. The peripheral circadian rhythms of the other soma...