Effect of Sex and Assay Method on Serum Concentrations of Growth Hormone in Patients with Acromegaly and in Healthy Controls

From: Clinical Chemistry | Date: March 1, 2006| Author: | Copyright information

Background: Diagnosis and follow-up of acromegaly is based on measurements of serum growth hormone (GH) concentrations during an oral glucose tolerance test (OGTT). A nadir value <1 µg/L is commonly used to define a normal response, but some authors suggest lower cutoff values.

Methods: To compare the results and subsequent patient classification obtained with 3 GH assays, we obtained basal serum samples from 78 apparently healthy adult controls (43 women and 35 men; median age, 32.5 years) and from 71 treated (44 women and 27 men; median age, 55.2 years) and 7 untreated acromegaly ...

Read all of this article with a FREE trial to HighBeam Research

Related newspaper, magazine, and trade journal articles from HighBeam Research

(Including press releases, facts, information, and biographies)

Growth Hormone (GH) Receptor Isoform in Acromegaly: Lower Concentrations of GH but Not Insulin-Like Growth Factor-1 in Patients with a Genomic Deletion of Exon 3 in the GH Receptor Gene
; ...group (P = not significant). Basal GH concentrations were higher in the fl-GHR group...nadir (20.5 vs 5.1 g/L, P = 0.003) GH concentrations during an oral glucose tolerance...excess; in patients with acromegaly, GH concentrations are not suppressed to <1 g/L by...
Effects of selection for milk yield on growth hormone response to growth hormone releasing factor in growing Holstein calves
; ...after subtracting mean prechallenge GH concentrations. Data were analyzed for effects of...different when P < 0.05. Prechallenge GH concentrations did not differ between lines, were...Several studies have suggested that GH concentrations are greater in superior animals...
NT-proBNP concentration in Chinese apparently healthy individuals
; ...NT-proBNP) by age and gender in apparently healthy individuals-based study. Method The...and medical record review in 587 apparently healthy individuals(299 female and 288 male...analytical performance. Within the apparently healthy individuals, the distribution of...
Pre-anesthetic program can become standard in delivery of quality care
; ...are testing are discovering that apparently healthy young animals can and do have medical...for anesthesia induction, including apparently healthy animals under 6 years of age. We...were found in 13 percent of young, apparently healthy patients. With minimal effort to...
New cash aid for farmers in crisis
; ...news came as the first slaughter of apparently healthy sheep in Scotland got underway today...value. Meanwhile, the first cull of apparently healthy sheep targeted because of their proximity...said: "The process of taking out apparently healthy animals has started. These animals...
unraveling a mystery; Twenty-five years ago, young and apparently healthy Hmong men in America were dying in their sleep. Theories abounded but no one was certain of the cause. With a renewed influx of Hmong to the Twin Cities, will that answer finally come?(VARIETY)
; ...their beds, at night, in their sleep. Apparently healthy, most between the ages of 25 and...said. In the 1980s, at least 117 apparently healthy Southeast Asian refugees to the United...didn't answer the question: Why were apparently healthy Hmong men in America dying in their...
Circulating Concentrations of Growth-Differentiation Factor 15 in Apparently Healthy Elderly Individuals and Patients with Chronic Heart Failure as Assessed by a New Immunoradiometric Sandwich Assay
; ...circulating GDF15 concentrations in 429 apparently healthy elderly individuals and 153 patients...resistant to 4 freeze-thaw cycles. Apparently healthy, elderly individuals presented with...confounding variables defined for apparently healthy elderly individuals and the favorable...
Slaughter airfield opens for business
; ...the Army-led operation to cull hundreds of thousands of apparently healthy animals finally began. After days of debate and preparation...stop the spread of the disease in Gloucestershire. The apparently healthy animals, at Cattle Country adventure park in Berkeley...
Slaughter airfield opens for business.
; ...the Army-led operation to cull hundreds of thousands of apparently healthy animals finally began. After days of debate and preparation...stop the spread of the disease in Gloucestershire. The apparently healthy animals, at Cattle Country adventure park in Berkeley...
FARMER'S DIARY: ROG WOOD
; ...news, congregating to publicly protest at the cull of apparently healthy animals. With such a cavalier disregard for the way the...the new cases now appearing on farms that where to have apparently healthy animals slaughtered. That reinforces the argument for...