The Diverse Biological Functions of Phosphatidylinositol Transfer Proteins in Eukaryotes

From: Critical Reviews in Biochemistry and Molecular Biology | Date: January 1, 2006| Author: | Copyright information

ABSTRACT Phosphatidylinositol/phosphatidylcholine transfer proteins (PITPs) remain largely functionally uncharacterized, despite the fact that they are highly conserved and are found in all eukaryotic cells thus far examined by biochemical or sequence analysis approaches. The available data indic ate a role for PITPs in regulating specific interfaces between lipid-signaling and cellular function. In this regard, a role for PITPs in controlling specific membrane trafficking events is emerging as a common functional theme. However, the mechanisms by which PITPs regulate lipid-signaling and ...

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