High Drug Prices Return As Issue That Stirs Voters; New Challenges for a Lobby Used to Spending -- and Winning

To celebrate another victorious year, the Pharmaceutical Research and Manufacturers of America last March played a videotape featuring one of the drug industry's archenemies, Rep. Bernard Sanders (I- Vt.).

"Mr. Speaker, even the New York Yankees sometimes lose, and it has been known that, on occasion, the Los Angeles Lakers lose a ballgame," Sanders, a staunch proponent of legislation that would control drug prices, was shown proclaiming bitterly to his colleagues. "But one organization never loses, and that organization has hundreds of victories to its credit and zero defeats in…