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serine
serine
serine An aliphatic, polar (see
POLAR MOLECULE)
alpha-amino acid. It is often associated with the active site of an
enzyme.
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D-Serine inhibits AMPA receptor-mediated current in rat hippocampal neurons.([alpha]-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate)(Report)
Magazine article from: Canadian Journal of Physiology and Pharmacology; 5/1/2007; ; 700+ words
; Abstract: D-Serine, a recently identified gliotransmitter...the present study, we showed that D-serine was able to concentration-dependently...hippocampal neurons. The blocking action of D-serine on AMPA receptors was characterized by...
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A serine protease from the midgut of the bumblebee, Bombus ignitus (Hymenoptera: Apidae): cDNA cloning, gene structure, expression and enzyme activity
Magazine article from: European Journal of Entomology; 1/1/2007; ; 700+ words
; ...bumblebee, cDNA cloning, enzyme, expression, gene structure, serine protease Abstract. A serine protease gene was cloned from the bumblebee, Bombus ignitus. The B. ignitus serine protease (BiSP) gene spans 1702 bp and consists of four introns...
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Simultaneous Analysis of D- and L-Serine in Cerebrospinal Fluid by Use of HPLC
Magazine article from: Clinical Chemistry; 8/1/2007; ; 700+ words
; Background: D-Serine is a coagonist for the glycine-binding site...We developed an HPLC method for D- and L-serine in cerebrospinal fluid (CSF). Methods: The dabsylated racemic serine peak, automatically collected using a previously...
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Genome-wide survey of prokaryotic serine proteases: Analysis of distribution and domain architectures of five serine protease families in prokaryotes.(Research article)
Magazine article from: BMC Genomics; 11/19/2008; ; 700+ words
; ...in living systems [1, 2, 3, 4]. Serine proteases are ubiquitous enzymes with...families grouped into clans. Over 50 serine protease families are currently classified...tumors [6, 7, 8, 9]. Thus, many serine proteases and their substrates are attractive...
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 "The Economist (US)")
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Neurobiology: Mirror, mirror.(research into D-serine amino acid indicates that it may be involved in regulating NMDA brain receptors)(Brief Article)
Magazine article from: The Economist (US); 11/20/1999; 700+ words
; ...researchers found an amino acid called D-serine in mammalian brains. Unlike all other amino acids found in animals, D-serine is right-handed. Ever since, researchers...have found an enzyme that converts serine from the normal left-handed form...
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Serine proteases appear to modulate vascular function and angiogenesis.
Newspaper article from: Angiogenesis Weekly; 5/9/2003; 700+ words
; ...NewsRx.com & NewsRx.net) -- Serine proteases appear to modulate vascular function and angiogenesis. "Many serine proteases play important regulatory...angiogenesis. Here we provide evidence that serine protease activities, independent of...
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Corvas And Dyax Collaborate On Serine Protease Inhibitors.
Newspaper article from: Cancer Weekly; 10/30/2001; 700+ words
; ...commercialization of novel cancer therapeutics focused on serine protease inhibitors. Serine proteases, the largest human protease gene family...protein fragments), and antibodies that bind to two serine protease targets isolated and characterized by...
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Mammalian target of rapamycin regulates IRS-1 serine phosphorylation.
Newspaper article from: Diabetes Week; 5/31/2004; 674 words
; ...insulin receptor substrate (IRS)-1 serine 307 phosphorylation. According to published...negatively regulated by phosphorylation of serine 307 of the insulin receptor substrate...inhibitor of the kinase mTOR, can prevent serine 307 phosphorylation and the development...
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Serine proteases and metalloproteases associated with pathogenesis but not host specificity in the entomophthoralean fungus Zoophthora radicans.
Magazine article from: Canadian Journal of Microbiology; 6/1/2006; ; 700+ words
; ...All strains produced three distinct serine proteases ranging in size from 25 to...fungus. A cDNA encoding a trypsin-like serine protease, ZrSP1, was also identified and was most similar to a serine protease from the plant pathogen Verticillium...
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Corvas and Dyax Announce Discovery of Fully Human Monoclonal Antibodies Against Endothelial Serine Proteases.
Business Wire; 4/11/2003; 700+ words
; ...novel cancer therapeutics focused on serine protease inhibitors. Utilizing Dyax...Endotheliase I and II, two proprietary serine protease targets discovered at Corvas. Endotheliases are a subfamily of serine proteases that are expressed by endothelial...
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serine
Book article from: The Columbia Encyclopedia, Sixth Edition
serine , organic compound, one of the 20 amino...other metabolites, including glycine . Serine is important in metabolism in that it participates...incorporated into the structure of enzymes, serine often plays an important role in their catalytic...
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Post-translational Control
Book article from: Genetics
...side chain, usually to the side chain hydroxyl (-OH) of serine, threonine, or tyrosine. This modification results from the...amino acid asparagine or to the hydroxyl of the amino acids serine or threonine. The structure of these carbohydrates can be complex...
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Phospholipids
Book article from: Chemistry: Foundations and Applications
...phosphate group in phosphatidate with an alcohol, such as serine, ethanolamine, choline, glyercol, or inositol. The resulting lipids may be charged, for example, phosphatidyl serine (PS), phosphatidyl inositol (PI), and phosphatidyl...
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Residue
Book article from: Chemistry: Foundations and Applications
...amino acid and its position. Therefore, if residue 45 in a particular polypeptide sequence is serine, that residue would be referred to as serine-45. see also Peptide Bond; Primary Structure; Proteins. Robert Noiva Bibliography Berg, Jeremy...
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Glycoprotein
Book article from: Chemistry: Foundations and Applications
...the asparagine is followed by some other amino acid and then a serine or threonine residue (-Asn-Xaa-Ser/Thr). Carbohydrate...the addition of sugar residues to the hydroxyl side chain of serine or threonine residues in polypeptides in the Golgi apparatus...
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