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point mutation

A Dictionary of Biology | 2004 | © A Dictionary of Biology 2004, originally published by Oxford University Press 2004. (Hide copyright information) Copyright

point mutation (gene mutation) A change in the nucleotide sequence of the DNA within a gene; a gene in which such a change has occurred is known as a mutant gene or allele (see mutation). The DNA sequence can be altered in several ways; for example by insertion, substitution, deletion, and inversion. Point mutations result in a misreading of the genetic code during the translation phase of protein synthesis and usually change the order of amino acids making up a protein, which may or may not affect the function of that protein. See also intergenic suppressor; missense mutation. Compare chromosome mutation; single nucleotide polymorphism.

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