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antagonist

A Dictionary of Biology | 2004 | © A Dictionary of Biology 2004, originally published by Oxford University Press 2004. (Hide copyright information) Copyright

antagonist A drug that inhibits the effect of an agonist in such a way that the combined biological effect of the two substances becomes smaller than the sum of their individual effects. Competitive antagonists act by binding to agonist receptors, while noncompetitive antagonists do not bind to the same receptor sites as the agonist. A functional antagonist binds to other receptors that elicit an effect opposite to that of the agonist.

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