Organs and Organ Systems
Organs and Organ Systems
Many forensic examinations include an autopsy . The surgical inspection of the exterior and interior of a body can reveal details about the death, including signs of trauma, wounds, and the presence of poisons, drugs or toxins .
Examination of various organs (two or more different types of tissue that work together to carry out a complex function) and organ systems (a group of organs that perform intricate functions necessary for the survival of an organism) is of paramount importance in an autopsy, since they can be the targets of the physical and chemical damage.
Sometimes an organism can survive with an impaired or nonfunctioning organ. However, when a whole system of organs shuts down, the life of the organism becomes compromised. Thus, the organ systems work together to maintain a constant internal environment, called homeostasis, within the body to ensure survival of the organism. The physical and chemical insults that are of forensic relevance (e.g., disease, use of firearms or poisons, drowning, asphyxiation) can disastrously disrupt the homeostatic balance.
There are 11 organ systems within the human body: integumentary, skeletal, muscular, nervous, endocrine, circulatory, lymphatic, respiratory, digestive, urinary, and reproductive.
The integumentary system acts as a protective barrier for the human body against microorganisms, dehydration, and injuries caused by the outside environment. Additionally, the integumentary system regulates body temperature. Organs of the integumentary system include hair, nails, sebaceous glands, sudoriferous glands, and the largest organ of the body, the skin.
The skeletal system is a structural framework providing support, shape, and protection to the human body. Additionally, the skeletal system provides attachment sites for organs. The skeletal system also stores minerals and lipids and forms blood cells. Bones, cartilage, tendons, and ligaments are all organs of the skeletal system.
The muscular system provides movement to the human body as a whole, as well as movement of materials through organs and organ systems. This system also functions to maintain posture and produce heat. The muscular system consists of skeletal muscle, smooth muscle, and cardiac muscle.
The nervous system conducts electrical impulses throughout the body to regulate and control physiological processes of the other organ systems. Organs of the nervous system include the brain, spinal cord, and nerves.
The endocrine system also functions to regulate and control physiological processes of the body. However, these functions are accomplished by sending out chemical signals called hormones into the blood. Glands, the organs of the endocrine system, secrete hormones and include: the pituitary gland, pineal gland, hypothalamus, thyroid gland, parathyroid glands, thymus, adrenal glands, pancreas, ovaries, and the testes.
The circulatory system circulates blood throughout the body and in doing so transports gases, nutrients, and wastes to and from tissues. Organs of the circulatory system include the heart, blood vessels, and blood.
The lymphatic system, also known as the immune system , defends the body against microorganisms and other foreign bodies. Additionally, fluids are transported from the body's tissues to the blood, thus helping to control fluid balance in the body. This system also absorbs substances from the digestive system. The organs of the lymphatic system include the lymph, lymph nodes, lymph vessels, thymus, spleen, and tonsils.
The respiratory system exchanges gases between the body's tissues and the external environment. Oxygen is inhaled from the external environment and passes from the lungs into the blood, where it is exchanged for carbon dioxide that passes from the blood to the lungs and is expelled. The respiratory system consists of the nose, pharynx, larynx, trachea, bronchi, and lungs.
The digestive system functions to digest and absorb nutrients from the food ingested into the body. Additionally, the digestive system transports foodstuff through the gastrointestinal tract. The primary organs of the digestive system include the mouth, pharynx, esophagus, stomach, small intestine, large intestine, rectum, and anal canal. Accessory organs that aid the primary organs include the teeth, salivary glands, tongue, liver, gallbladder, pancreas, and appendix.
The urinary system removes excess water and nutrients and filters wastes from the circulatory system. Additionally, the urinary system aids in red blood cell formation and metabolizes vitamin D. The urinary system's organs include the kidneys, ureters, urinary bladder, and urethra.
The reproductive system of the human body can be either male or female. The male reproductive system synthesizes gametes called spermatozoa that are responsible for fertilizing the female gametes, or oocytes, during reproduction. The female reproductive system is designed to undergo conception, gestation, and birth once a spermatozoon fertilizes an oocyte. The male reproductive system is composed of the testes, vas deferens, urethra, penis,
scrotum, and prostate. The female reproductive system consists of the ovaries, uterus, fallopian tubes, vagina, vulva, and mammary glands.
see also Autopsy; Decomposition; Poison and antidote actions; Toxicology.
Cite this article
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Pilocarpine may be toxic to retinal ganglion cells
Magazine article from: Ophthalmology Times; 9/15/1999; ; 700+ words
; PHILADELPHIA-Pilocarpine has been one of the mainstays of...ciliary muscle contraction. However, pilocarpine has been shown to be neurotoxic in...in the early 1980s, showed that pilocarpine was very good at generating seizures...
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Ultrasonic study to see the effect of topical pilocarpine and homatropine on anterior chamber depth in phakic cases.(Original Article)(Report)
Magazine article from: Indian Journal of Ophthalmology; 1/1/1992; ; 700+ words
; ...Mehrotra, ILA. Gupta, B. Chouhan Pilocarpine and Homatropine are the drugs having...chamber, after single instillation of pilocarpine 2% or homatropine bromide 2%, topically...eye, due to systemic absorption of pilocarpine, homatropine after topical instillation...
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Primary argon laser trabeculoplasty vs pilocarpine 2% in open angle glaucoma : Two years follow-up study.(Original Article)(Clinical report)
Magazine article from: Indian Journal of Ophthalmology; 3/1/1997; ; 700+ words
; ...ALT) was evaluated and compared with pilocarpine 2% as primary treatment in newly diagnosed...one eye each of 26 patients received pilocarpine 2% every 8 hours. The mean pre-treatment...24.47[+ or -]3.51 mmHg in the pilocarpine group. The mean post treatment IOP...
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A comparative evaluation of pilocarpine 1% and clonidine 0.125% versus timolol 0.5%.(Original Article)
Magazine article from: Indian Journal of Ophthalmology; 3/1/1996; ; 700+ words
; ...response of open angle glaucoma eyes to pilocarpine 1%, clonidine 0.125%, a combination of pilocarpine 1% and clonidine 0.125%, and timolol...the effectivity of the combination of pilocarpine 1% and clonidine 0.125% was significantly...
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PHARMOS SUCCESSFULLY COMPLETES PHASE II TRIAL OF PILOCARPINE-SME ON 60 GLAUCOMA PATIENTS
PR Newswire; 2/3/1994; 700+ words
; ...patients with glaucoma using Pharmos' proprietary SubMicron Emulsion (SME) formulation of pilocarpine, known as Pilocarpine-SME, Standard pilocarpine treatment involves four applications of eyedrops daily and results in side effects leading...
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PRODUCTION OF PILOCARPINE IN CALLUS OF JABORANDI (PILOCARPUS MICROPHYLLUS STAPF)
Magazine article from: In Vitro Cellular & Developmental Biology; 11/1/2005; ; 700+ words
; ...microphyllus) is the only known source of pilocarpine, and although this alkaloid is the...were also kept under continuous light. Pilocarpine was identified in the liquid medium...released the greatest quantities of pilocarpine into the medium. Methyljasmonate inhibited...
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Oral therapy with pilocarpine promising for dry eye
Magazine article from: Ophthalmology Times; 6/15/2000; ; 700+ words
; ...Treatment with oral sustained-release pilocarpine (Salagen, MGI Pharma) may be effective...Health Sciences University, Portland. "Pilocarpine is a cholinergic parasympathomimetic...with dry mouth The sustained-release pilocarpine preparation is indicated for treatment...
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Comparative evaluation of pilocarpine 2% and combined guanethidine 1% & adrenaline 0.5% in the treatment of chronic simple glaucoma.(Original Article)
Magazine article from: Indian Journal of Ophthalmology; 5/1/1987; ; 700+ words
; ...results of a comparative study between pilocarpine 2%, Guanethidine 1 % &adrenaline...be a useful alternative treatment to pilocarpine 2% used alone Introduction Adrenaline...guanethidine and adrenaline. Group II: Using pilocarpine. Each group consisted of 25 patients...
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Lannett Company Receives FDA Approval for Pilocarpine HCI Tablets 7.5 mg Strength.
Business Wire; 5/8/2009; 700+ words
; ...Abbreviated New Drug Application (ANDAs) for Pilocarpine HCI tablets, 7.5 mg, the generic...previously received and currently markets Pilocarpine HCI tablets, in the 5 mg strength...sales in 2008 of both generic and brand Pilocarpine HCI 7.5 mg tablets were $2.5 million...
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Lannett's pilocarpine ANDA cleared by FDA.
Newspaper article from: Pharma Marketletter; 5/18/2009; 508 words
; ...Abbreviated New Drug Application for pilocarpine tablets, 7.5mg, the generic equivalent...previously received and currently markets pilocarpine tablets, in the 5mg strength. According...sales in 2008 of both generic and brand pilocarpine 7.5mg tablets were $2.5 million...
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Pilocarpine
Encyclopedia entry from: Gale Encyclopedia of Cancer
Pilocarpine Definition Pilocarpine is a medicine used to treat xerostomia , or dryness of the mouth...that is characterized by the failure of the exocrine glands. Pilocarpine is also known as pilocarpine hydrochloride or Salagen. Purpose...
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pilocarpine
Book article from: The Columbia Encyclopedia, Sixth Edition
pilocarpine , naturally occurring alkaloid obtained from plants of the genus Pilocarpus (family Rutaceae). By mimicking the effects of acetylcholine , pilocarpine acts as a stimulant of the parasympathetic nervous system . It promotes...
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Sweat Test
Encyclopedia entry from: Gale Encyclopedia of Children's Health: Infancy through Adolescence
...water or bicarbonate and the other in pilocarpine, a drug that stimulates sweating...for five to ten minutes to carry the pilocarpine into the skin. This stimulates the...paper is taped to the area where the pilocarpine was applied. The paper is then covered...
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Dry Mouth
Encyclopedia entry from: Gale Encyclopedia of Alternative Medicine
...as a treatment for dry mouth related to cancer therapy. Pilocarpine hydrochloride (Salagen) is a drug that was approved in...more moisture. A study published in 2002 indicates that pilocarpine also relieves dry mouth in cancer patients. Cevimeline...
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Ethnobotany
Book article from: Plant Sciences
...collecting information about plants and fungi from indigenous peoples around the world. Dozens of modern medicines, such as pilocarpine, which is used for treating glaucoma, have active ingredients that came to light through ethnobotanical investigations...
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