Personal Computers
PERSONAL COMPUTERS
Personal computers (PC) were developed during the 1970s and were intended for use by small businesses and in the home. No established industrial computer company, like IBM, Burroughs, or Honeywell believed in 1975 that there would be any market for a PC. The earliest commercial PCs were credited to the efforts of Stephen Jobs (1955—) and Stephen Wozniak (1950—), who began their own PC company, Apple Computers, in 1976, building a microchip-based computer for small businesses and particularly for home use. These computers represented simplicity of design and function, and they were easily used by non-professionals. By 1977 the personal computer industry moved quickly, with Apple, Commodore, and Radio Shack aggressively entering the "home computer market."
The PC was made possible largely because of the miniaturization of electronic parts and the ability to reliably mass produce many parts of the computer, such as the silicon chip, the integrated circuit board, and the microprocessor. The personal computer evolved (in the 1960s and 1970s) from large single-function devices like industrial data processors to smaller single-function devices like pocket calculators. With smaller hardware and more diverse software, the PC of the late 1970s became consolidated into desktop sized, multi-function devices. They now provide international communications, word-processing capabilities, as well as the other educational, recreational, and personal functions associated with modern computers in homes and businesses.
See also: Computer Industry, Stephen Jobs, Stephen Wozniak
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Histamine-induced itch and its relationship with pain.(Review)
Magazine article from: Molecular Pain; 7/31/2008; ; 700+ words
; ...pruritogenic agents, see [3, 4]), histamine is best known to evoke experimental itch...that we understand the manner in which histamine induces itch. In this regard, it is...mainly on experimental findings concerning histamine-induced itch. Histamine and itch Histamine...
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Histamine may aid in battle against tumors
Magazine article from: Dermatology Times; 12/1/1999; ; 700+ words
; ...a naturally occurring molecule called histamine, researchers can better stimulate an...leading cancer centers are testing whether histamine added to immunotherapy agents will improve...their tumor-killing ability. When histamine is added to immunotherapy, it attaches...
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Histamine: putative transmitter for lateral inhibition in Limulus eye. (horseshoe crab)
Magazine article from: The Biological Bulletin; 10/1/1997; ; 700+ words
; ...mediates lateral inhibition in the Limulus eye? Histamine has been implicated as a photoreceptor neurotransmitter...preparations that study the postsynaptic effects of histamine, histamine has been shown to be inhibitory (7, 8). Biochemical...
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The H1 histamine receptor regulates allergic lung responses.(Research article)(includes statistical table)
Magazine article from: Journal of Clinical Investigation; 6/1/2006; ; 700+ words
; Histamine, signaling via the type 1 receptor...Further investigation revealed that histamine acts as a T cell chemotactic factor and...Cultured T cells migrated in response to histamine in vitro, but this was ablated by blockade...
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Different roles of histamine receptor subtypes in ampullar & isthmic segments of human fallopian tube
Magazine article from: Indian Journal of Medical Research; 5/1/1998; ; 700+ words
; ...the influence of both menstrual cycle phase and subtype-selective histamine antagonists on the contractions produced by histamine isolated in human fallopian tubes. Histamine produced tonic contractions of the isolated preparations of both the...
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IMMUNOHISTOCHEMICAL LOCALIZATION OF HISTAMINE RECEPTOR SUBTYPES IN HUMAN INFERIOR TURBINATES
Magazine article from: The Annals of Otology, Rhinology & Laryngology; 7/1/2004; ; 700+ words
; Histamine is an important chemical mediator in...the immunohistochemical localization of histamine receptor subtypes (H1R, H2R, H3R...study was to examine the distribution of histamine receptor subtypes in the human inferior...
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Benefits of a histamine-reducing diet for some patients with chronic urticaria and angioedema
Magazine article from: Canadian Journal of Dietetic Practice and Research; 4/1/2000; ; 700+ words
; ...primarily from the physiological actions of histamine. Some individuals with urticaria have a decreased ability to degrade dietary histamine before it enters the circulation. Foods high in histamine, such as fermented foods, may exacerbate...
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Genetic variability of histamine receptors in patients with Parkinson's disease.(Research article)
Magazine article from: BMC Medical Genetics; 3/17/2008; ; 700+ words
; ...AG Agúndez [3] Background Histamine is involved in neuronal degeneration...patients [3]. It has been shown that histamine causes selective damage in the dopaminergic...4]. Among patients with PD, blood histamine levels [5] and the concentration of...
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Macrophages may uptake histamine for clearance by L-histidine decarboxylase.
Newspaper article from: Biotech Week; 10/15/2003; 700+ words
; ...Macrophages may uptake excess histamines for clearance by L-histidine...demonstrated that dietary histamine is accumulated in the spleens...mice, which lack endogenous histamine synthesis. "To characterize...clearance system for dietary histamine in mice, we investigated...
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Histamine 2 blocker potentiates the effects of histamine 1 blocker in suppressing histamine-induced wheal
Magazine article from: Indian Journal of Dermatology, Venereology and Leprology; 9/1/2008; ; 700+ words
; Introduction Histamine is a major mediator in allergic reactions...locally and systemically. [1] Four histamine receptors have been identified. H 1...in the flare reaction. The action of histamine on bronchial smooth muscle and blood...
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Histamine 2 Antagonists
Encyclopedia entry from: Gale Encyclopedia of Cancer
Histamine 2 antagonists Definition Histamine 2 antagonists are drugs that block the production of acid in the stomach. Purpose Histamine 2 antagonists are used to treat the precancerous condition...
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Histamine
Book article from: World of Microbiology and Immunology
Histamine Histamine is a hormone that is chemically similar to the hormones serotonine...another cell or tissue located elsewhere in the body. Specifically, histamine plays a role in localized immune responses and in allergic reactions...
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histamine
Book article from: The Columbia Encyclopedia, Sixth Edition
histamine , organic compound derived in the body...found in many plant and animal tissues, histamine is specifically important in human physiology...certain types of antibodies. Released histamine tends to dilate blood capillaries, often...
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Antihistamine
Book article from: Medical Discoveries
...stomach upset and diarrhea as well. Histamine was first recognized and suggested...1881-1940) in 1910. By 1932 histamines were confirmed as causative agents...on this problem in 1936. Since histamine is extremely toxic except when...
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Allergies
Book article from: World of Microbiology and Immunology
...to discharge its histamines and other anti...are two types of histamine: H 1 and H 2 . H 1 histamines travel to receptor...the production of histamine or block them at...the release of the histamines that cause the allergic...
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