Receptor: NMDA (N-Methyl D-Aspartic Acid)
RECEPTOR: NMDA (N-METHYL D-ASPARTIC ACID)
The NMDA receptor is a protein on the surface of neurons (nerve cells). When the major excitatory Neurotransmitter, Glutamate, binds to this protein, the central pore of the NMDA receptor channel opens—then cations (the ions of sodium, potassium, and calcium) are able to cross the cell membrane. The movement of cations through the pore results in neuronal excitation.
The NMDA receptor is one of several cell receptor surface proteins activated by glutamate. The Hallucinogen Phencyclidine (PCP) blocks the open channel of the NMDA receptor preventing cation flow. It is believed that overactivation of the NMDA receptor could be responsible for the neuronal cell death observed following some forms of stroke; it may even be involved in the cell death associated with neurodegenerative diseases.
(See also: Neurotransmission ; Receptor ; Drug )
BIBLIOGRAPHY
Choi, D. (1988). Glutamate neurotoxicity and diseases of the nervous system. Neuron, 1, 623-634.
Collingridge, G., & Lester, R. (1989). Excitatory amino acid receptors in the vertebrate central nervous system. Pharmacology Reviews, 40 (2), 145-210.
Mayer, M. L., & Westbrook, G. L. (1987). The physiology of excitatory amino acids in the vertebrate central nervous system. Progress in Neurobiology, 28, 197-276.
George R. Uhl
Valina Dawson
Cite this article
Pick a style below, and copy the text for your bibliography.
UHL, GEORGE R.; VALINA DAWSON. "Receptor: NMDA (N-Methyl D-Aspartic Acid)." Encyclopedia of Drugs, Alcohol, and Addictive Behavior. The Gale Group Inc. 2001. Encyclopedia.com. 29 Nov. 2009 <http://www.encyclopedia.com>.
UHL, GEORGE R.; VALINA DAWSON. "Receptor: NMDA (N-Methyl D-Aspartic Acid)." Encyclopedia of Drugs, Alcohol, and Addictive Behavior. The Gale Group Inc. 2001. Encyclopedia.com. (November 29, 2009). http://www.encyclopedia.com/doc/1G2-3403100396.html
UHL, GEORGE R.; VALINA DAWSON. "Receptor: NMDA (N-Methyl D-Aspartic Acid)." Encyclopedia of Drugs, Alcohol, and Addictive Behavior. The Gale Group Inc. 2001. Retrieved November 29, 2009 from Encyclopedia.com: http://www.encyclopedia.com/doc/1G2-3403100396.html
Learn more about citation styles
 "Morning Call (Allentown, PA)")
|
Whiskey flows again at Ireland's Kilbeggan distillery: Spirits / John Hansell.
Newspaper article from: Morning Call (Allentown, PA); 8/1/2007; 700+ words
; ...than Irish. The whiskey is distilled twice...traditional for Irish whiskey. And they even make smoky whiskeys, like those you...shop selling Cooley whiskeys. But, for the first...in over 50 years, whiskey is being produced...
|
|
Whiskey galore
Newspaper article from: The Irish Times; 9/26/2009; 700+ words
; ...INHALE THE AROMAS of a 12-year- old whiskey and words such as vanilla and honey come...seem so potent. The fragrances of this whiskey remind me of Christmas cake, and I find...peaty, smoky Scotch and sweet Tennessee whiskey beside it. This is the taste test at...
|
|
Whiskey reigns supreme
Newspaper article from: International Herald Tribune; 12/5/2008; ; 700+ words
; ...with the potency of whiskey can be a difficult proposition...overall quality of the whiskeys was excellent, and...Distillers can issue whiskeys at any age they want...statement at all. We wanted whiskeys of roughly the same...malts. The longer a whiskey is aged, the more of...
|
|
|
Irish whiskey: The legend continues Spirits
Newspaper article from: International Herald Tribune; 3/9/2006; ; 700+ words
; ...Irish and Scotch whiskeys?In its purest form, Irish whiskey has a fresh, lightly...their own way as the whiskeys they produce. The whiskey was distilled from...column-still grain whiskey. Both are good whiskeys, but they didn...
|
 "Rocky Mountain News (Denver, CO)")
|
A WHISKEY WORTH THE WAIT 'SUPER PREMIUM' PRODUCT OF STATE'S FIRST LICENSED DISTILLERY AGES IN BARRELS FOR 2006 RELEASE.(Business)
Newspaper article from: Rocky Mountain News (Denver, CO); 2/5/2005; ; 700+ words
; ...55 a bottle for his whiskey. Super premium whiskeys are among the fastest...calling it a Colorado whiskey because our process...than most traditional whiskeys," Graber said. INFOBOX Colorado's first whiskey * What: Stranahan...
|
|
In Washington, whiskey becomes a meal, not a drink
Newspaper article from: Chicago Sun-Times; 4/27/1989; ; 700+ words
; Drinking whiskey may lead to ruination, but cooking with...a town that has a lot to say about whiskey. One current statement on the subject...hotel, the Ritz-Carlton, I thought any whiskey would be probably disguised. I was half...
|
|
Whiskey River Running Dry for Distiller's Claim to Texas.
Newspaper article from: Knight Ridder/Tribune Business News; 7/9/2003; 700+ words
; ...Tribune Business News Jul. 9--McKendric's whiskey is reportedly distilled in Kentucky and bottled...with rawhide -- McKendric Mesquite-Mellowed Whiskey. It is a sippin' whiskey that evokes the image of the West. In fact, the...
|
 "Daily Herald (Arlington Heights, IL)")
|
Whiskey lovers trace roots to colonial days, Europe.(Food)
Newspaper article from: Daily Herald (Arlington Heights, IL); 3/13/2002; 700+ words
; ...beginning, it was the juice of the barley - whiskey - that America took delight in, and still...grain were converted into amber ripples of whiskey. To explore American and international...s sellout event, I learned that each whiskey, like each wine, results from a unique...
|
|
Whiskey on the move; American whiskey adds fans and moves drinks as the industry discovers the draw of ultra-premium offerings.
Magazine article from: Cheers; 9/1/2008; ; 700+ words
; ...only ones enthusiastic about whiskey today. "Bourbon and other American whiskeys continue to be the best value in the world whiskey market," says John Hansell...magazine. "Relative to competing whiskeys like Scotch, Bourbon matures...
|
|
Irish whiskey: the other Celtic spirit.
Magazine article from: New Hampshire Business Review; 4/27/2007; ; 700+ words
; ...line of Irish whiskeys. As with scotch...day when tasting whiskey, dampening the...single-malt whiskey and grain whiskeys aged in bourbon...character Irish whiskeys are known for...this single malt whiskey. Aged 10 years...
|
|
Whiskey
Book article from: How Products Are Made
Whiskey Background Whiskey (usually spelled whisky in Canada and Scotland) is a spirit produced...certainly existed in Europe no later than 500 years ago. Some claim that whiskey was invented in Ireland as long as 1,000 years ago and carried to...
|
|
whiskey
Book article from: The Columbia Encyclopedia, Sixth Edition
whiskey [from the Gaelic...or corn. Inferior whiskeys are made from potatoes...are matured. Irish whiskey resembles Scotch...taste. American whiskeys are divided into...bourbon, a corn whiskey that derives its...
|
|
Whiskey (Whisky)
Encyclopedia entry from: Encyclopedia of Food and Culture
WHISKEY (WHISKY) WHISKEY (WHISKY). The spelling "whiskey" is common for Irish whiskeys and the vast majority of U.S...and occasionally for some U.S. whiskeys. The word "whisky"/"whiskey" is derived from the Irish and...
|
|
Whiskey Rebellion
Encyclopedia entry from: West's Encyclopedia of American Law
WHISKEY REBELLION In 1794 thousands of farmers...tax on distilled spirits. Known as the "Whiskey Rebellion," this insurrection represented...Revolution and the Civil War. A number of the whiskey rebels were prosecuted for treason in what...
|
|
The Whiskey Rebellion
Book article from: The Oxford Companion to American Military History
The Whiskey Rebellion (1794) originated in a dispute...Many of the leaders simply fled. If the Whiskey Rebellion had little military significance...in August 1794, the suppression of the Whiskey Rebellion marked the emergence of the national...
|
