HIV-1 evades antibody-mediated neutralization by masking receptor-binding sites.

AIDS Weekly | January 27, 2003 | Copyright

2003 JAN 27 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "The ability of human immunodeficiency virus (HIV-1) to persist and cause AIDS is dependent on its avoidance of antibody-mediated neutralization. The virus elicits abundant, envelope-directed antibodies that have little neutralization capacity. This lack of neutralization is paradoxical, given the functional conservation and exposure of receptor-binding sites on the gp120 envelope glycoprotein, which are larger than the typical antibody footprint and should therefore be accessible for ...

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