Quercetin glucuronides inhibited 2-aminofluorene acetylation, in human acute myeloid HL-60 leukemia cells.

From: Phytomedicine: International Journal of Phytotherapy &Phytopharmacology | Date: October 1, 2002| Author: | Copyright information

Summary

Our earlier study has demonstrated that following the exposure of rat to the arylamine carcinogen 2-aminofluorene, DNA-2-aminofluorene adducts were found in the target tissues liver, bladder, colon, lung and also in circulating leukocytes (lymphocytes and monocytes). The result also demonstrated that orally treated antioxidants decreased N-acetylation of 2-aminofluorene in target tissues and leukocytes. Therefore, this study investigated whether quercetin glucuronides could affect N-acetylation of 2-aminofluorene in human acute myeloid leukemia HL-60 cells. Evidence ...

Read all of this article with a FREE trial to HighBeam Research

Related newspaper, magazine, and trade journal articles from HighBeam Research

(Including press releases, facts, information, and biographies)

Quercetin glucuronides but not glucosides are present in human plasma after consumption of quercetin-3-glucoside or quercetin-4-glucoside
; ...Metabolism Research Communication Quercetin Glucuronides but Not Glucosides Are Present...consumption of quercetin glucosides, quercetin glucuronides are major metabolites in plasma...2001. KEY WORDS: - flavonoids- quercetin glucuronides intestinal absorption - human...
Digoxin-Like Immunoreactive Factors Induce Apoptosis in Human Acute T-Cell Lymphoblastic Leukemia
; ...nmol/L). Conclusion: DLIF selectively induces apoptosis in a human acute T-cell lymphoblastic leukemia cell line but not in K-562 cells...the proapoptotic actions of digoxin, ouabain, and DLIF in a human acute T-cell lymphoblastic leukemic cell line (Jurkat E6-1), a human...
Rapid detection of Flt3 mutations in acute myeloid leukemia patients by denaturing HPLC
; ...tyrosine kinase 3 (Flt3) is the most commonly mutated gene in human acute myeloid leukemia (AML) and has been implicated in its pathogenesis...tyrosine kinase 3 (Flt3)1 is the most commonly mutated gene in human acute myeloid leukemia (AML), and has been implicated in its pathogenesis...
Tissue Distribution of Quercetin in Rats and Pigs1
; ...quercetin, which may help to understand its mechanisms of action in vivo. J. Nutr. 135: 1718-1725, 2005. KEY WORDS: * quercetin * glucuronides * tissue distribution * flavonoids * polyphenols Quercetin is a plant-derived, dietary compound with potentially beneficial...
Analysis of protein binding in the myeloid-lymphoid leukemia gene translocation breakpoint cluster region.(COMMUNICATIONS--UNDERGRADUATE)(Clinical report)
; ...gene fuses to greater than 50 different loci as the result of reciprocal translocations associated with several subtypes of human acute leukemia. In every case, the fusion point in MLL is within the same 8.3 kilobase pair (kbp) region, called the MLL breakpoint...
Assessing DNA topoisomerase binding in the myeloid-lympoid leukemia gene translocation breakpoint region.(COMMUNICATIONS--UNDERGRADUATE)(Report)
; ...leukemia gene, (MLL), breaks and fuses to one of >50 different translocation partner genes in several subtypes of de novo human acute leukemia. All breaks in MLL occur within the same 8 kilobase (kb) region, (bcr) and create in-frame fusion mRNAs and fusion...
Finding Unexpected Patterns in Microarray Data1
; ...Arabidopsis grown under different light/dark conditions, Arabidopsis exposed to different types of biotic and abiotic stress, and human acute leukemia. We find, for instance, that light has a dramatic effect on plants despite the absence of the four major photoreceptors...
DR. GEORGE FOLEY, HELPED FOUND CANCER FOUNDATION
; ...Center and a lecturer in the Department of Pathology at the Harvard Medical School. He also achieved the first isolation of human acute leukemic lymphoblast cells in continuous culture. He was the author of the Children's Cancer Research Foundation book, "The...
Molecular and immunological characterisation of Fasciola species
; ...gigantica between pH 3.5 and pH 10. Although many bands appear common to both species, some are species-specific. Six cases of human acute fascioliasis diagnosed clinically, haematologically and immunologically are also studied. Gel immunodiffusion and immunoelectrophoresis...
Biphenotypic acute leukemia with coexpression of CD79a and markers of myeloid lineage
; ...biphenotypic acute leukemia in which CD79a expression was observed in the blast population. (Arch Pathol Lab Med. 2003;127:356-359) Human acute leukemias are broadly defined as having myeloid or lymphoid differentiation according to the expression of surface and/or...