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Weak protein-protein interactions can drive assembly of HBV capsids.
Hepatitis Weekly
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December 9, 2002
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COPYRIGHT 2002 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group.
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2002 DEC 9 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "Hepatitis B virus (HBV) is an enveloped DNA virus with a spherical capsid (or core). The capsid is constructed from 120 copies of the homodimeric capsid protein arranged with T = 4 icosahedral symmetry. We examined in vitro assembly of purified E. coli expressed HBV capsid protein."
P. Ceres and colleagues, University of Oklahoma, used size exclusion chromatography to determine concentrations of the HBV capsid and dimer after equilibration.
"The extent of assembly ...
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