ACADIA Discovers Novel Small Molecule Leads for the V2 Vasopressin Receptor; Chemical-Genomics Platform Enables Discovery of Small Molecule Activators Of Numerous Peptide GPCRs.

PR Newswire | September 26, 2002 | Copyright

SAN DIEGO and COPENHAGEN, Denmark -- ACADIA Pharmaceuticals announced today the discovery of small molecule lead chemistries for the V2 Vasopressin receptor. The V2 Vasopressin receptor is the major control mechanism for the production of urine. Activation of this receptor by ACADIA's lead compounds resulted in a sustained decrease in urine production in preclinical animal models.

"While V2 peptides that require injection or nasal application have long been used to treat diabetes insipidus, bleeding disorders, and nocturnal uresis (bed wetting), an orally active ...

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