Mitogen-activated protein kinase activation by oxidative and bacterial stress in an amphibian cell culture model. (Research Articles).

From: Environmental Health Perspectives | Date: July 1, 2002| Author: Carter, Lisa A.; Tabor, Maija B.; Bonner, James C.; Bonner, Lisa A. | Copyright information

The decline of many amphibian species could be caused by their susceptibility to environmental pollutants that cause cellular stress and cell death. A variety of intracellular signal transduction pathways are activated by environmental stress factors, which result in cell death. Mitogen-activated protein kinases are intracellular signaling molecules that include the extracellular signal-regulated kinases (ERK-1 and ERK-2). We used cultured Xenopus tadpole cells (XTC-2 cells) to inv...

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