Designing telomerase inhibitors. (Chemistry Paper Abstracts).(Brief Article)
From: Journal of the Idaho Academy of Science
|
Date: 6/1/2001
|
Author: Han, Xiaochun; Hobdey, Kevin; Kang, ChulHee; Natale, Nick; Zhou, Peiwen
Kevin Hobdey*
A Lanthanide catalyzed double activation technique was used to combine known anti-viral and anti-tumor moieties. The resulting series of compounds was designed to inhibit telomerase activity within cancer tumor cells by stabilizing the quadruplex (G-4) conformation of DNA. NSC-D 694332 is the first of this series to show single digit micromolar inhibition of more than six tumor cell lines. Molecular modeling ...
Read all of this article with a FREE trial to HighBeam
(This preview shows 439 of 883 characters)
COPYRIGHT 2001 Idaho Academy of Science
This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group.
For permission to reuse this article, contact Copyright Clearance Center.