Estrogen metabolism and the diet-cancer connection: rationale for assessing the ratio of urinary hydroxylated estrogen metabolites. (Estrogen Metabolism/Cancer Review).

From: Alternative Medicine Review | Date: April 1, 2002| Author: Lord, Richard S.; Bongiovanni, Bradley; Bralley, J. Alexander | Copyright information

Abstract

Estrogens are known for their proliferative effects on estrogen-sensitive tissues resulting in tumorigenesis. Results of experiments in multiple laboratories over the last 20 years have shown that a large part of the cancer-inducing effect of estrogen involves the formation of agonistic metabolites of estrogen, especially 16[alpha]-hydroxyestrone. Other metabolites, such as 2-hydroxyestrone and 2-hydroxyestradiol, offer protection against the estrogen-agonist e...

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