Male with deterioration of mental status. (Pathologic Quiz Case).(cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy)

Archives of Pathology & Laboratory Medicine | January 1, 2002| | Copyright

A 62-year-old white man presented with a 3-year history of progressive mental decline, including deterioration in memory and speech. He also experienced gait abnormalities and dysphagia. He had a family history significant for several relatives who had similar problems, some of whom died secondary to this condition. The patient had no significant past medical history and had been otherwise healthy. A neurologic examination was significant for decreased short-term memory, slurred speech, and a left peripheral VIIth nerve palsy.

Magnetic resonance imaging showed ...

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